KMS Of Academy of mathematics and systems sciences, CAS
Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains | |
Liu, Zhi-Ping2,3; Wang, Yong1; Zhang, Xiang-Sun1; Chen, Luonan2,3,4 | |
2010-09-13 | |
发表期刊 | BMC SYSTEMS BIOLOGY |
ISSN | 1752-0509 |
卷号 | 4页码:12 |
摘要 | Background: Alzheimer's disease (AD) is a major neurodegenerative disorder leading to amnesia, cognitive impairment and dementia in the elderly. Usually this type of lesions results from dysfunctional protein cooperations in the biological pathways. In addition, AD progression is known to occur in different brain regions with particular features. Thus identification and analysis of crosstalk among dysregulated pathways as well as identification of their clusters in various diseased brain regions are expected to provide deep insights into the pathogenetic mechanism. Results: Here we propose a network-based systems biology approach to detect the crosstalks among AD related pathways, as well as their dysfunctions in the six brain regions of AD patients. Through constructing a network of pathways, the relationships among AD pathway and its neighbor pathways are systematically investigated and visually presented by their intersections. We found that the significance degree of pathways related to the fatal disorders and the pathway overlapping strength can indicate the impacts of these neighbored pathways to AD development. Furthermore, the crosstalks among pathways reveal some evidence that the neighbor pathways of AD pathway closely cooperate and play important tasks in the AD progression. Conclusions: Our study identifies the common and distinct features of the dysfunctional crosstalk of pathways in various AD brain regions. The global pathway crosstalk network and the clusters of relevant pathways of AD provide evidence of cooperativity among pathways for potential pathogenesis of the neuron complex disease. |
DOI | 10.1186/1752-0509-4-S2-S11 |
语种 | 英语 |
WOS研究方向 | Mathematical & Computational Biology |
WOS类目 | Mathematical & Computational Biology |
WOS记录号 | WOS:000208294800010 |
出版者 | BIOMED CENTRAL LTD |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.amss.ac.cn/handle/2S8OKBNM/234 |
专题 | 应用数学研究所 |
通讯作者 | Zhang, Xiang-Sun |
作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, SIBS Novo Nordisk Translat Res Ctr PreDiabet, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 4.Univ Tokyo, Inst Ind Sci, Tokyo 1538505, Japan |
推荐引用方式 GB/T 7714 | Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,et al. Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains[J]. BMC SYSTEMS BIOLOGY,2010,4:12. |
APA | Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2010).Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains.BMC SYSTEMS BIOLOGY,4,12. |
MLA | Liu, Zhi-Ping,et al."Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains".BMC SYSTEMS BIOLOGY 4(2010):12. |
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