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Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains
Liu, Zhi-Ping2,3; Wang, Yong1; Zhang, Xiang-Sun1; Chen, Luonan2,3,4
2010-09-13
Source PublicationBMC SYSTEMS BIOLOGY
ISSN1752-0509
Volume4Pages:12
AbstractBackground: Alzheimer's disease (AD) is a major neurodegenerative disorder leading to amnesia, cognitive impairment and dementia in the elderly. Usually this type of lesions results from dysfunctional protein cooperations in the biological pathways. In addition, AD progression is known to occur in different brain regions with particular features. Thus identification and analysis of crosstalk among dysregulated pathways as well as identification of their clusters in various diseased brain regions are expected to provide deep insights into the pathogenetic mechanism. Results: Here we propose a network-based systems biology approach to detect the crosstalks among AD related pathways, as well as their dysfunctions in the six brain regions of AD patients. Through constructing a network of pathways, the relationships among AD pathway and its neighbor pathways are systematically investigated and visually presented by their intersections. We found that the significance degree of pathways related to the fatal disorders and the pathway overlapping strength can indicate the impacts of these neighbored pathways to AD development. Furthermore, the crosstalks among pathways reveal some evidence that the neighbor pathways of AD pathway closely cooperate and play important tasks in the AD progression. Conclusions: Our study identifies the common and distinct features of the dysfunctional crosstalk of pathways in various AD brain regions. The global pathway crosstalk network and the clusters of relevant pathways of AD provide evidence of cooperativity among pathways for potential pathogenesis of the neuron complex disease.
DOI10.1186/1752-0509-4-S2-S11
Language英语
WOS Research AreaMathematical & Computational Biology
WOS SubjectMathematical & Computational Biology
WOS IDWOS:000208294800010
PublisherBIOMED CENTRAL LTD
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Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/234
Collection应用数学研究所
Corresponding AuthorZhang, Xiang-Sun
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, SIBS Novo Nordisk Translat Res Ctr PreDiabet, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China
4.Univ Tokyo, Inst Ind Sci, Tokyo 1538505, Japan
Recommended Citation
GB/T 7714
Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,et al. Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains[J]. BMC SYSTEMS BIOLOGY,2010,4:12.
APA Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2010).Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains.BMC SYSTEMS BIOLOGY,4,12.
MLA Liu, Zhi-Ping,et al."Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains".BMC SYSTEMS BIOLOGY 4(2010):12.
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