Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

doi:10.1186/1752-0509-4-S2-S11

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	Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains
	Liu, Zhi-Ping 2,3; Wang, Yong1 ; Zhang, Xiang-Sun1 ; Chen, Luonan 2,3,4
	2010-09-13
发表期刊	BMC SYSTEMS BIOLOGY
ISSN	1752-0509
卷号	4 页码:12
摘要	Background: Alzheimer's disease (AD) is a major neurodegenerative disorder leading to amnesia, cognitive impairment and dementia in the elderly. Usually this type of lesions results from dysfunctional protein cooperations in the biological pathways. In addition, AD progression is known to occur in different brain regions with particular features. Thus identification and analysis of crosstalk among dysregulated pathways as well as identification of their clusters in various diseased brain regions are expected to provide deep insights into the pathogenetic mechanism. Results: Here we propose a network-based systems biology approach to detect the crosstalks among AD related pathways, as well as their dysfunctions in the six brain regions of AD patients. Through constructing a network of pathways, the relationships among AD pathway and its neighbor pathways are systematically investigated and visually presented by their intersections. We found that the significance degree of pathways related to the fatal disorders and the pathway overlapping strength can indicate the impacts of these neighbored pathways to AD development. Furthermore, the crosstalks among pathways reveal some evidence that the neighbor pathways of AD pathway closely cooperate and play important tasks in the AD progression. Conclusions: Our study identifies the common and distinct features of the dysfunctional crosstalk of pathways in various AD brain regions. The global pathway crosstalk network and the clusters of relevant pathways of AD provide evidence of cooperativity among pathways for potential pathogenesis of the neuron complex disease.
DOI	10.1186/1752-0509-4-S2-S11
语种	英语
WOS研究方向	Mathematical & Computational Biology
WOS类目	Mathematical & Computational Biology
WOS记录号	WOS:000208294800010
出版者	BIOMED CENTRAL LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/234
专题	应用数学研究所
通讯作者	Zhang, Xiang-Sun
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, SIBS Novo Nordisk Translat Res Ctr PreDiabet, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 4.Univ Tokyo, Inst Ind Sci, Tokyo 1538505, Japan
推荐引用方式 GB/T 7714	Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,et al. Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains[J]. BMC SYSTEMS BIOLOGY,2010,4:12.
APA	Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2010).Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains.BMC SYSTEMS BIOLOGY,4,12.
MLA	Liu, Zhi-Ping,et al."Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains".BMC SYSTEMS BIOLOGY 4(2010):12.