Genetic risks and genetic model specification

doi:10.1016/j.jtbi.2016.05.016

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	Genetic risks and genetic model specification
	Zheng, Gang 1; Zhang, Wei 2; Xu, Jinfeng 3; Yuan, Ao 4; Li, Qizhai2 ; Gastwirth, Joseph L.5
	2016-08-21
发表期刊	JOURNAL OF THEORETICAL BIOLOGY
ISSN	0022-5193
卷号	403 页码:68-74
摘要	Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy Weinberg equilibrium in cases using genetic relative risk. Extensive simulations demonstrate that the power of a study to detect associations using odds ratio is lower than that using relative risk with the same value when other parameters are fixed. When the Hardy Weinberg equilibrium holds in the general population, the genetic model can be inferred by the deviation from Hardy Weinberg equilibrium in only cases. Furthermore, it is more efficient than that based on the deviation from Hardy-Weinberg equilibrium in all cases and controls. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Case-control design Genetic model Genetic risk Hardy-Weinberg equilibrium
DOI	10.1016/j.jtbi.2016.05.016
语种	英语
资助项目	National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Chinese Academy of Sciences[XDB13040600]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS类目	Biology ; Mathematical & Computational Biology
WOS记录号	WOS:000378987100008
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/23075
专题	系统科学研究所
通讯作者	Yuan, Ao
作者单位	1.NHLBI, Bldg 10, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 3.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China 4.Georgetown Univ, Washington, DC 20057 USA 5.George Washington Univ, Washington, DC USA
推荐引用方式 GB/T 7714	Zheng, Gang,Zhang, Wei,Xu, Jinfeng,et al. Genetic risks and genetic model specification[J]. JOURNAL OF THEORETICAL BIOLOGY,2016,403:68-74.
APA	Zheng, Gang,Zhang, Wei,Xu, Jinfeng,Yuan, Ao,Li, Qizhai,&Gastwirth, Joseph L..(2016).Genetic risks and genetic model specification.JOURNAL OF THEORETICAL BIOLOGY,403,68-74.
MLA	Zheng, Gang,et al."Genetic risks and genetic model specification".JOURNAL OF THEORETICAL BIOLOGY 403(2016):68-74.