KMS Of Academy of mathematics and systems sciences, CAS
| Genetic risks and genetic model specification | |
Zheng, Gang1; Zhang, Wei2; Xu, Jinfeng3; Yuan, Ao4; Li, Qizhai2 ; Gastwirth, Joseph L.5
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| 2016-08-21 | |
| Source Publication | JOURNAL OF THEORETICAL BIOLOGY
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| ISSN | 0022-5193 |
| Volume | 403Pages:68-74 |
| Abstract | Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy Weinberg equilibrium in cases using genetic relative risk. Extensive simulations demonstrate that the power of a study to detect associations using odds ratio is lower than that using relative risk with the same value when other parameters are fixed. When the Hardy Weinberg equilibrium holds in the general population, the genetic model can be inferred by the deviation from Hardy Weinberg equilibrium in only cases. Furthermore, it is more efficient than that based on the deviation from Hardy-Weinberg equilibrium in all cases and controls. (C) 2016 Elsevier Ltd. All rights reserved. |
| Keyword | Case-control design Genetic model Genetic risk Hardy-Weinberg equilibrium |
| DOI | 10.1016/j.jtbi.2016.05.016 |
| Language | 英语 |
| Funding Project | National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Chinese Academy of Sciences[XDB13040600] |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
| WOS Subject | Biology ; Mathematical & Computational Biology |
| WOS ID | WOS:000378987100008 |
| Publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/23075 |
| Collection | 系统科学研究所 |
| Corresponding Author | Yuan, Ao |
| Affiliation | 1.NHLBI, Bldg 10, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 3.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China 4.Georgetown Univ, Washington, DC 20057 USA 5.George Washington Univ, Washington, DC USA |
| Recommended Citation GB/T 7714 | Zheng, Gang,Zhang, Wei,Xu, Jinfeng,et al. Genetic risks and genetic model specification[J]. JOURNAL OF THEORETICAL BIOLOGY,2016,403:68-74. |
| APA | Zheng, Gang,Zhang, Wei,Xu, Jinfeng,Yuan, Ao,Li, Qizhai,&Gastwirth, Joseph L..(2016).Genetic risks and genetic model specification.JOURNAL OF THEORETICAL BIOLOGY,403,68-74. |
| MLA | Zheng, Gang,et al."Genetic risks and genetic model specification".JOURNAL OF THEORETICAL BIOLOGY 403(2016):68-74. |
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