Genetic risks and genetic model specification

doi:10.1016/j.jtbi.2016.05.016

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	Genetic risks and genetic model specification
	Zheng, Gang 1; Zhang, Wei 2; Xu, Jinfeng 3; Yuan, Ao 4; Li, Qizhai2 ; Gastwirth, Joseph L.5
	2016-08-21
Source Publication	JOURNAL OF THEORETICAL BIOLOGY
ISSN	0022-5193
Volume	403 Pages:68-74
Abstract	Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy Weinberg equilibrium in cases using genetic relative risk. Extensive simulations demonstrate that the power of a study to detect associations using odds ratio is lower than that using relative risk with the same value when other parameters are fixed. When the Hardy Weinberg equilibrium holds in the general population, the genetic model can be inferred by the deviation from Hardy Weinberg equilibrium in only cases. Furthermore, it is more efficient than that based on the deviation from Hardy-Weinberg equilibrium in all cases and controls. (C) 2016 Elsevier Ltd. All rights reserved.
Keyword	Case-control design Genetic model Genetic risk Hardy-Weinberg equilibrium
DOI	10.1016/j.jtbi.2016.05.016
Language	英语
Funding Project	National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Chinese Academy of Sciences[XDB13040600]
WOS Research Area	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS Subject	Biology ; Mathematical & Computational Biology
WOS ID	WOS:000378987100008
Publisher	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics	Cited Times:1[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.amss.ac.cn/handle/2S8OKBNM/23075
Collection	系统科学研究所
Affiliation	1.NHLBI, Bldg 10, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 3.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China 4.Georgetown Univ, Washington, DC 20057 USA 5.George Washington Univ, Washington, DC USA
Recommended Citation GB/T 7714	Zheng, Gang,Zhang, Wei,Xu, Jinfeng,et al. Genetic risks and genetic model specification[J]. JOURNAL OF THEORETICAL BIOLOGY,2016,403:68-74.
APA	Zheng, Gang,Zhang, Wei,Xu, Jinfeng,Yuan, Ao,Li, Qizhai,&Gastwirth, Joseph L..(2016).Genetic risks and genetic model specification.JOURNAL OF THEORETICAL BIOLOGY,403,68-74.
MLA	Zheng, Gang,et al."Genetic risks and genetic model specification".JOURNAL OF THEORETICAL BIOLOGY 403(2016):68-74.

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