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An on-chip model for investigating the interaction between neurons and cancer cells
Lei, Yifeng1; Li, Jun1; Wang, Nuoxin1; Yang, Xinglong1; Hamada, Yoh2; Li, Qizhai3; Zheng, Wenfu1; Jiang, Xingyu1
2016
Source PublicationINTEGRATIVE BIOLOGY
ISSN1757-9694
Volume8Issue:3Pages:359-367
AbstractEmerging evidence suggests that there is extensive interaction between neurons and cancer cells. However, few model systems have been developed to investigate nerve-cancer cell interaction in vitro. Herein, a high-throughput microfluidic compartmentalized chip is developed to examine the interaction between neurons and cancer cells. The nerve bundles appear to provide a biophysical support for cancer cells and guide their directional migration. The cancers that have high levels of perineural invasion in clinical observations exhibit greater migration along neurites in the on-chip model. The on-chip model allows the screening of compounds which inhibit cancer cell migration along neurites in vitro. The interruption of neurites, the pharmacological blockade of nerve-cancer signaling, effectively attenuates the migration of cancer cells along neurites. This on-chip model provides a useful platform to investigate the dynamic interaction between cancer cells and neurons and can dramatically broaden the chemical space in screening neuron-related drugs for cancers.
DOI10.1039/c5ib00309a
Language英语
Funding ProjectCAS[XDA09030305] ; CAS/SAFEA ; NSFC[81361140345] ; NSFC[31470911] ; China Postdoctoral Science Foundation[2014M550672] ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000372256400010
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/22310
Collection系统科学研究所
Affiliation1.Natl Ctr NanoSci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China
2.Tohoku Univ, Grad Sch Med, Dept Nanomed Sci, Sendai, Miyagi 9808575, Japan
3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
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GB/T 7714
Lei, Yifeng,Li, Jun,Wang, Nuoxin,et al. An on-chip model for investigating the interaction between neurons and cancer cells[J]. INTEGRATIVE BIOLOGY,2016,8(3):359-367.
APA Lei, Yifeng.,Li, Jun.,Wang, Nuoxin.,Yang, Xinglong.,Hamada, Yoh.,...&Jiang, Xingyu.(2016).An on-chip model for investigating the interaction between neurons and cancer cells.INTEGRATIVE BIOLOGY,8(3),359-367.
MLA Lei, Yifeng,et al."An on-chip model for investigating the interaction between neurons and cancer cells".INTEGRATIVE BIOLOGY 8.3(2016):359-367.
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