An on-chip model for investigating the interaction between neurons and cancer cells

doi:10.1039/c5ib00309a

CSpace > 系统科学研究所

	An on-chip model for investigating the interaction between neurons and cancer cells
	Lei, Yifeng 1; Li, Jun 1; Wang, Nuoxin 1; Yang, Xinglong 1; Hamada, Yoh 2; Li, Qizhai3 ; Zheng, Wenfu 1; Jiang, Xingyu 1
	2016
发表期刊	INTEGRATIVE BIOLOGY
ISSN	1757-9694
卷号	8 期号:3 页码:359-367
摘要	Emerging evidence suggests that there is extensive interaction between neurons and cancer cells. However, few model systems have been developed to investigate nerve-cancer cell interaction in vitro. Herein, a high-throughput microfluidic compartmentalized chip is developed to examine the interaction between neurons and cancer cells. The nerve bundles appear to provide a biophysical support for cancer cells and guide their directional migration. The cancers that have high levels of perineural invasion in clinical observations exhibit greater migration along neurites in the on-chip model. The on-chip model allows the screening of compounds which inhibit cancer cell migration along neurites in vitro. The interruption of neurites, the pharmacological blockade of nerve-cancer signaling, effectively attenuates the migration of cancer cells along neurites. This on-chip model provides a useful platform to investigate the dynamic interaction between cancer cells and neurons and can dramatically broaden the chemical space in screening neuron-related drugs for cancers.
DOI	10.1039/c5ib00309a
语种	英语
资助项目	CAS[XDA09030305] ; CAS/SAFEA ; NSFC[81361140345] ; NSFC[31470911] ; China Postdoctoral Science Foundation[2014M550672] ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000372256400010
出版者	ROYAL SOC CHEMISTRY
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/22310
专题	系统科学研究所
通讯作者	Zheng, Wenfu; Jiang, Xingyu
作者单位	1.Natl Ctr NanoSci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Tohoku Univ, Grad Sch Med, Dept Nanomed Sci, Sendai, Miyagi 9808575, Japan 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lei, Yifeng,Li, Jun,Wang, Nuoxin,et al. An on-chip model for investigating the interaction between neurons and cancer cells[J]. INTEGRATIVE BIOLOGY,2016,8(3):359-367.
APA	Lei, Yifeng.,Li, Jun.,Wang, Nuoxin.,Yang, Xinglong.,Hamada, Yoh.,...&Jiang, Xingyu.(2016).An on-chip model for investigating the interaction between neurons and cancer cells.INTEGRATIVE BIOLOGY,8(3),359-367.
MLA	Lei, Yifeng,et al."An on-chip model for investigating the interaction between neurons and cancer cells".INTEGRATIVE BIOLOGY 8.3(2016):359-367.