KATZLDA: KATZ measure for the lncRNA-disease association prediction
Chen, Xing1,2
AbstractAccumulating experimental studies have demonstrated important associations between alterations and dysregulations of lncRNAs and the development and progression of various complex human diseases. Developing effective computational models to integrate vast amount of heterogeneous biological data for the identification of potential disease-lncRNA associations has become a hot topic in the fields of human complex diseases and lncRNAs, which could benefit lncRNA biomarker detection for disease diagnosis, treatment, and prevention. Considering the limitations in previous computational methods, the model of KATZ measure for LncRNA-Disease Association prediction (KATZLDA) was developed to uncover potential lncRNA-disease associations by integrating known lncRNA-disease associations, lncRNA expression profiles, lncRNA functional similarity, disease semantic similarity, and Gaussian interaction profile kernel similarity. KATZLDA could work for diseases without known related lncRNAs and lncRNAs without known associated diseases. KATZLDA obtained reliable AUCs of 7175, 0.7886, 0.7719 in the local and global leave-one-out cross validation and 5-fold cross validation, respectively, significantly improving previous classical methods. Furthermore, case studies of colon, gastric, and renal cancer were implemented and 60% of top 10 predictions have been confirmed by recent biological experiments. It is anticipated that KATZLDA could be an important resource with potential values for biomedical researches.
Funding ProjectNational Natural Science of Foundation of China[11301517] ; National Center for Mathematics and Interdisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000364903300002
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Document Type期刊论文
Corresponding AuthorChen, Xing
Affiliation1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
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Chen, Xing. KATZLDA: KATZ measure for the lncRNA-disease association prediction[J]. SCIENTIFIC REPORTS,2015,5:11.
APA Chen, Xing.(2015).KATZLDA: KATZ measure for the lncRNA-disease association prediction.SCIENTIFIC REPORTS,5,11.
MLA Chen, Xing."KATZLDA: KATZ measure for the lncRNA-disease association prediction".SCIENTIFIC REPORTS 5(2015):11.
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