Over-expression of EPS15 is a favorable prognostic factor in breast cancer

doi:10.1039/c5mb00219b

CSpace > 应用数学研究所

	Over-expression of EPS15 is a favorable prognostic factor in breast cancer
	Dai, Xiaofeng 1,2,3; Liu, Zhaoqi 4; Zhang, Shihua4
	2015
发表期刊	MOLECULAR BIOSYSTEMS
ISSN	1742-206X
卷号	11 期号:11 页码:2978-2985
摘要	As a crucial player in terminating growth factor signaling, EPS15 plays important roles in many malignancies including breast cancer. To explore the potential association of EPS15 with the clinical outcome of breast cancer, we conducted gene expression survival analysis using six independent datasets, checked its expression quantitative loci and their associated genes, and explored the networking of these genes with EPS15. Our results show that over-expression of EPS15 is significantly associated with a favorable clinical outcome of breast cancer, especially in tumors harbouring a positive estrogen receptor status. 21 unique SNPs were found to be associated with EPS15 expression. Among the neighboring genes of these SNPs, five (MTUS1, DOCK5, MSRA, SLIT3 and SKAP1) are genetically connected with EPS15 and its physical partners. These genes including EPS15 also show significant concurrent expressions, and four exhibit distinct relevance regarding patient survival. High expressions of EPS15 and MSRA show a distinct combinatorial favorable survival, suggesting the clinical relevance of their co-activation. In summary, over-expression of EPS15 is a potential favorable prognostic marker in breast cancer, which can be used clinically alone or together with other genes such as MSRA to avail therapeutic decision-making.
DOI	10.1039/c5mb00219b
语种	英语
资助项目	National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[31471251] ; Fundamental Research Funds for the Central Universities[JUSRP11507] ; Foundation for Members of Youth Innovation Promotion Association ; CAS ; Outstanding Young Scientist Program of CAS ; Scientific Research Foundation for ROCS, SEM ; Key Laboratory of Random Complex Structures and Data Science, CAS
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000362950000015
出版者	ROYAL SOC CHEMISTRY
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/20986
专题	应用数学研究所
通讯作者	Zhang, Shihua
作者单位	1.Jiang Nan Univ, Sch Biotechnol, Natl Engn Lab Cereal Fermentat Technol, Wuxi 214122, Peoples R China 2.Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland 3.Univ Helsinki, Cent Hosp, Helsinki, Finland 4.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Dai, Xiaofeng,Liu, Zhaoqi,Zhang, Shihua. Over-expression of EPS15 is a favorable prognostic factor in breast cancer[J]. MOLECULAR BIOSYSTEMS,2015,11(11):2978-2985.
APA	Dai, Xiaofeng,Liu, Zhaoqi,&Zhang, Shihua.(2015).Over-expression of EPS15 is a favorable prognostic factor in breast cancer.MOLECULAR BIOSYSTEMS,11(11),2978-2985.
MLA	Dai, Xiaofeng,et al."Over-expression of EPS15 is a favorable prognostic factor in breast cancer".MOLECULAR BIOSYSTEMS 11.11(2015):2978-2985.