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Over-expression of EPS15 is a favorable prognostic factor in breast cancer
Dai, Xiaofeng1,2,3; Liu, Zhaoqi4; Zhang, Shihua4
2015
Source PublicationMOLECULAR BIOSYSTEMS
ISSN1742-206X
Volume11Issue:11Pages:2978-2985
AbstractAs a crucial player in terminating growth factor signaling, EPS15 plays important roles in many malignancies including breast cancer. To explore the potential association of EPS15 with the clinical outcome of breast cancer, we conducted gene expression survival analysis using six independent datasets, checked its expression quantitative loci and their associated genes, and explored the networking of these genes with EPS15. Our results show that over-expression of EPS15 is significantly associated with a favorable clinical outcome of breast cancer, especially in tumors harbouring a positive estrogen receptor status. 21 unique SNPs were found to be associated with EPS15 expression. Among the neighboring genes of these SNPs, five (MTUS1, DOCK5, MSRA, SLIT3 and SKAP1) are genetically connected with EPS15 and its physical partners. These genes including EPS15 also show significant concurrent expressions, and four exhibit distinct relevance regarding patient survival. High expressions of EPS15 and MSRA show a distinct combinatorial favorable survival, suggesting the clinical relevance of their co-activation. In summary, over-expression of EPS15 is a potential favorable prognostic marker in breast cancer, which can be used clinically alone or together with other genes such as MSRA to avail therapeutic decision-making.
DOI10.1039/c5mb00219b
Language英语
Funding ProjectNational Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[31471251] ; Fundamental Research Funds for the Central Universities[JUSRP11507] ; Foundation for Members of Youth Innovation Promotion Association ; CAS ; Outstanding Young Scientist Program of CAS ; Scientific Research Foundation for ROCS, SEM ; Key Laboratory of Random Complex Structures and Data Science, CAS
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000362950000015
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/20986
Collection应用数学研究所
Corresponding AuthorZhang, Shihua
Affiliation1.Jiang Nan Univ, Sch Biotechnol, Natl Engn Lab Cereal Fermentat Technol, Wuxi 214122, Peoples R China
2.Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
3.Univ Helsinki, Cent Hosp, Helsinki, Finland
4.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Dai, Xiaofeng,Liu, Zhaoqi,Zhang, Shihua. Over-expression of EPS15 is a favorable prognostic factor in breast cancer[J]. MOLECULAR BIOSYSTEMS,2015,11(11):2978-2985.
APA Dai, Xiaofeng,Liu, Zhaoqi,&Zhang, Shihua.(2015).Over-expression of EPS15 is a favorable prognostic factor in breast cancer.MOLECULAR BIOSYSTEMS,11(11),2978-2985.
MLA Dai, Xiaofeng,et al."Over-expression of EPS15 is a favorable prognostic factor in breast cancer".MOLECULAR BIOSYSTEMS 11.11(2015):2978-2985.
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