KMS Of Academy of mathematics and systems sciences, CAS
Identifiability of models for clinical trials with noncompliance | |
Xie, TF; Zhang, ZZ | |
2004-08-01 | |
发表期刊 | DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B |
ISSN | 1531-3492 |
卷号 | 4期号:3页码:805-811 |
摘要 | In this article we focus on clinical trials in which the compliance is measured with random errors, and develop an error-in-variables model for the analysis of the clinical trials. With this model, we separate the efficacy of prescribed treatment from that of the compliance. With additional information correlated with compliance, we prove that the model is identifiable, and get estimators for the parameters of interest, including the parameter reflecting the efficacy of the treatment. Furthermore, we extend the model to stratified populations, and discuss the asymptotic properties of the estimators. |
关键词 | asymptotic normality clinical trial compliance EV model instrumental variable |
语种 | 英语 |
WOS研究方向 | Mathematics |
WOS类目 | Mathematics, Applied |
WOS记录号 | WOS:000221965100034 |
出版者 | AMER INST MATHEMATICAL SCIENCES |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.amss.ac.cn/handle/2S8OKBNM/19577 |
专题 | 中国科学院数学与系统科学研究院 |
通讯作者 | Xie, TF |
作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100081, Peoples R China 2.Beijing Univ Technol, Dept Appl Math, Beijing 100022, Peoples R China |
推荐引用方式 GB/T 7714 | Xie, TF,Zhang, ZZ. Identifiability of models for clinical trials with noncompliance[J]. DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B,2004,4(3):805-811. |
APA | Xie, TF,&Zhang, ZZ.(2004).Identifiability of models for clinical trials with noncompliance.DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B,4(3),805-811. |
MLA | Xie, TF,et al."Identifiability of models for clinical trials with noncompliance".DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B 4.3(2004):805-811. |
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