Identifiability of models for clinical trials with noncompliance

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	Identifiability of models for clinical trials with noncompliance
	Xie, TF ; Zhang, ZZ
	2004-08-01
发表期刊	DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B
ISSN	1531-3492
卷号	4 期号:3 页码:805-811
摘要	In this article we focus on clinical trials in which the compliance is measured with random errors, and develop an error-in-variables model for the analysis of the clinical trials. With this model, we separate the efficacy of prescribed treatment from that of the compliance. With additional information correlated with compliance, we prove that the model is identifiable, and get estimators for the parameters of interest, including the parameter reflecting the efficacy of the treatment. Furthermore, we extend the model to stratified populations, and discuss the asymptotic properties of the estimators.
关键词	asymptotic normality clinical trial compliance EV model instrumental variable
语种	英语
WOS研究方向	Mathematics
WOS类目	Mathematics, Applied
WOS记录号	WOS:000221965100034
出版者	AMER INST MATHEMATICAL SCIENCES
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/19577
专题	中国科学院数学与系统科学研究院
通讯作者	Xie, TF
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100081, Peoples R China 2.Beijing Univ Technol, Dept Appl Math, Beijing 100022, Peoples R China
推荐引用方式 GB/T 7714	Xie, TF,Zhang, ZZ. Identifiability of models for clinical trials with noncompliance[J]. DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B,2004,4(3):805-811.
APA	Xie, TF,&Zhang, ZZ.(2004).Identifiability of models for clinical trials with noncompliance.DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B,4(3),805-811.
MLA	Xie, TF,et al."Identifiability of models for clinical trials with noncompliance".DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B 4.3(2004):805-811.