Family-based association tests for different family structures using pooled DNA

doi:10.1046/j.1529-8817.2005.00164.x

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	Family-based association tests for different family structures using pooled DNA
	Zou, GH ; Zhao, HY
	2005-07-01
发表期刊	ANNALS OF HUMAN GENETICS
ISSN	0003-4800
卷号	69 页码:429-442
摘要	DNA pooling is a cost-effective strategy for genomewise association studies to identify disease genes. In the context of family-based association studies, Risch & Teng (1998) mainly considered fan-lilies of identical structures to detect associations between genetic markers and disease, and suggested possible approaches to incorporating different family types without a thorough study of their properties. However, families collected in real genetic studies often have different structures and, more importantly, the informativeness of each,family structure depends on the disease model which is generally unknown. So there is a need to develop and investigate statistical methods to combine information from diverse family types. In this article, we propose a general strategy to incorporate different family types by assigning each family an "optimal" weight in association tests. In addition, we consider measurement errors in our analysis. When we evaluate our approach under different disease models and measurement errors, we find that our weighting scheme may lead to a substantial reduction in sample size required over the approach suggested by Risch & Teng (1998), and measurement errors may have significant impact on the required sample size when the error rates are not negligible.
关键词	family-based association study family structure DNA pooling measurement error sample size
DOI	10.1046/j.1529-8817.2005.00164.x
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000230637800008
出版者	BLACKWELL PUBLISHING
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/1927
专题	中国科学院数学与系统科学研究院
通讯作者	Zhao, HY
作者单位	1.Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zou, GH,Zhao, HY. Family-based association tests for different family structures using pooled DNA[J]. ANNALS OF HUMAN GENETICS,2005,69:429-442.
APA	Zou, GH,&Zhao, HY.(2005).Family-based association tests for different family structures using pooled DNA.ANNALS OF HUMAN GENETICS,69,429-442.
MLA	Zou, GH,et al."Family-based association tests for different family structures using pooled DNA".ANNALS OF HUMAN GENETICS 69(2005):429-442.