Monte Carlo implementation of supercoiled double-stranded DNA

CSpace

	Monte Carlo implementation of supercoiled double-stranded DNA
	Zhang, Y ; Zhou, HJ ; Ou-Yang, ZC
	2000-04-01
发表期刊	BIOPHYSICAL JOURNAL
ISSN	0006-3495
卷号	78 期号:4 页码:1979-1987
摘要	Metropolis Monte Carlo simulation is used to investigate the elasticity of torsionally stressed double-stranded DNA, in which twist and supercoiling are incorporated as a natural result of base-stacking interaction and backbone bending constrained by hydrogen bonds formed between DNA complementary nucleotide bases. Three evident regimes are found in extension versus torsion and force versus extension plots: a low-force regime in which over- and underwound molecules behave similarly under stretching; an intermediate-force regime in which chirality appears for negatively and positively supercoiled DNA and extension of underwound molecule is insensitive to the supercoiling degree of the polymer; and a large-force regime in which plectonemic DNA is fully converted to extended DNA and supercoiled DNA behaves quite like a torsionless molecule. The striking coincidence between theoretic calculations and recent experimental measurement of torsionally stretched DNA (Strick et al., Science. 271:1835, 1996; Biophys. J. 74:2016, 1998) strongly suggests that the interplay between base-stacking interaction and permanent hydrogen-bond constraint takes an important role in understanding the novel properties of elasticity of supercoiled DNA polymer.
语种	英语
WOS研究方向	Biophysics
WOS类目	Biophysics
WOS记录号	WOS:000086349500029
出版者	BIOPHYSICAL SOCIETY
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/15329
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Y
作者单位	1.Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China 2.Free Univ Berlin, Inst Theoret Phys, D-14195 Berlin, Germany 3.State Key Lab Sci & Engn Comp, Beijing 100080, Peoples R China 4.Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Y,Zhou, HJ,Ou-Yang, ZC. Monte Carlo implementation of supercoiled double-stranded DNA[J]. BIOPHYSICAL JOURNAL,2000,78(4):1979-1987.
APA	Zhang, Y,Zhou, HJ,&Ou-Yang, ZC.(2000).Monte Carlo implementation of supercoiled double-stranded DNA.BIOPHYSICAL JOURNAL,78(4),1979-1987.
MLA	Zhang, Y,et al."Monte Carlo implementation of supercoiled double-stranded DNA".BIOPHYSICAL JOURNAL 78.4(2000):1979-1987.