Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments

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	Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments
	Zhou, HJ ; Zhang, Y ; Ou-Yang, ZC
	2000-07-01
发表期刊	PHYSICAL REVIEW E
ISSN	1063-651X
卷号	62 期号:1 页码:1045-1058
摘要	This paper aims at a comprehensive understanding of the novel elastic property of double-stranded DNA (dsDNA) discovered very recently through single-molecule manipulation techniques. A general elastic model for double-stranded biopolymers is proposed, and a structural parameter called the folding angle cp is introduced to characterize their deformations. The mechanical property of long dsDNA molecules is then studied based on this model, where the base-stacking interactions between DNA adjacent nucleotide base pairs, the steric effects of base pairs, and the electrostatic interactions along DNA backbones are taken into account. Quantitative results are obtained by using a path integral method and excellent agreement between theory and the observations reported by five major experimental groups are attained. The strong intensity of the base stacking interactions ensures the structural stability of DNA, while the short-ranged nature of such interactions makes externally stimulated large structural fluctuations possible. The entropic elasticity, highly extensibility, and supercoiling property of DNA are all closely related to this account. The present work also suggests the possibility that negative torque can induce structural transitions in highly extended DNA from the right-handed B form to left-handed configurations similar to the Z-form configuration. Some formulas concerned with the application of path integral methods to polymeric systems are listed in the Appendixes.
语种	英语
WOS研究方向	Physics
WOS类目	Physics, Fluids & Plasmas ; Physics, Mathematical
WOS记录号	WOS:000088274200035
出版者	AMERICAN PHYSICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/15151
专题	中国科学院数学与系统科学研究院
通讯作者	Zhou, HJ
作者单位	1.Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China 2.State Key Lab Sci & Engn Comp, Beijing 100080, Peoples R China 3.Tsing Hua Univ, Inst Adv Study, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Zhou, HJ,Zhang, Y,Ou-Yang, ZC. Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments[J]. PHYSICAL REVIEW E,2000,62(1):1045-1058.
APA	Zhou, HJ,Zhang, Y,&Ou-Yang, ZC.(2000).Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments.PHYSICAL REVIEW E,62(1),1045-1058.
MLA	Zhou, HJ,et al."Elastic property of single double-stranded DNA molecules: Theoretical study and comparison with experiments".PHYSICAL REVIEW E 62.1(2000):1045-1058.