Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations

doi:10.1080/02664763.2010.529881

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	Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations
	Li, Q.1 ; Zheng, G.2; Tiwari, R.3
	2011
发表期刊	JOURNAL OF APPLIED STATISTICS
ISSN	0266-4763
卷号	38 期号:9 页码:1833-1843
摘要	The trend test is often used for the analysis of 2 x K ordered categorical data, in which K pre-specified increasing scores are used. There have been discussions on how to assign these scores and the impact of the outcomes on different scores. The scores are often assigned based on the data-generating model. When this model is unknown, using the trend test is not robust. We discuss the weighted average of a trend test over all scientifically plausible choices of scores or models. This approach is more computationally efficient than a commonly used robust test MAX when K is large. Our discussion is for any ordered 2 x K table, but simulation and applications to real data are focused on case-control genetic association studies. Although there is no single test optimal for all choices of scores, our numerical results show that some score averaging tests can achieve the performance of MAX.
关键词	case-control genetic associations MAX ordered categorical data robustness score averaging tests trend tests
DOI	10.1080/02664763.2010.529881
语种	英语
资助项目	National Young Science Foundation of China[10901155]
WOS研究方向	Mathematics
WOS类目	Statistics & Probability
WOS记录号	WOS:000298921300006
出版者	TAYLOR & FRANCIS LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/12764
专题	系统科学研究所
通讯作者	Li, Q.
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.US Natl Heart Lung & Blood Inst, Off Biostat Res, Bethesda, MD 20892 USA 3.US FDA, Ctr Drug Evaluat & Res, Off Biostat, Silver Spring, MD 20993 USA
推荐引用方式 GB/T 7714	Li, Q.,Zheng, G.,Tiwari, R.. Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations[J]. JOURNAL OF APPLIED STATISTICS,2011,38(9):1833-1843.
APA	Li, Q.,Zheng, G.,&Tiwari, R..(2011).Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations.JOURNAL OF APPLIED STATISTICS,38(9),1833-1843.
MLA	Li, Q.,et al."Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations".JOURNAL OF APPLIED STATISTICS 38.9(2011):1833-1843.