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Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations
Li, Q.1; Zheng, G.2; Tiwari, R.3
2011
Source PublicationJOURNAL OF APPLIED STATISTICS
ISSN0266-4763
Volume38Issue:9Pages:1833-1843
AbstractThe trend test is often used for the analysis of 2 x K ordered categorical data, in which K pre-specified increasing scores are used. There have been discussions on how to assign these scores and the impact of the outcomes on different scores. The scores are often assigned based on the data-generating model. When this model is unknown, using the trend test is not robust. We discuss the weighted average of a trend test over all scientifically plausible choices of scores or models. This approach is more computationally efficient than a commonly used robust test MAX when K is large. Our discussion is for any ordered 2 x K table, but simulation and applications to real data are focused on case-control genetic association studies. Although there is no single test optimal for all choices of scores, our numerical results show that some score averaging tests can achieve the performance of MAX.
Keywordcase-control genetic associations MAX ordered categorical data robustness score averaging tests trend tests
DOI10.1080/02664763.2010.529881
Language英语
Funding ProjectNational Young Science Foundation of China[10901155]
WOS Research AreaMathematics
WOS SubjectStatistics & Probability
WOS IDWOS:000298921300006
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/12764
Collection系统科学研究所
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
2.US Natl Heart Lung & Blood Inst, Off Biostat Res, Bethesda, MD 20892 USA
3.US FDA, Ctr Drug Evaluat & Res, Off Biostat, Silver Spring, MD 20993 USA
Recommended Citation
GB/T 7714
Li, Q.,Zheng, G.,Tiwari, R.. Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations[J]. JOURNAL OF APPLIED STATISTICS,2011,38(9):1833-1843.
APA Li, Q.,Zheng, G.,&Tiwari, R..(2011).Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations.JOURNAL OF APPLIED STATISTICS,38(9),1833-1843.
MLA Li, Q.,et al."Analysis of ordered categorical data with score averaging: with applications to case-control genetic associations".JOURNAL OF APPLIED STATISTICS 38.9(2011):1833-1843.
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