Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients

doi:10.1039/c0mb00325e

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	Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients
	Liu, Zhi-Ping 1; Wang, Yong2 ; Zhang, Xiang-Sun2 ; Xia, Weiming 3; Chen, Luonan 1
	2011
发表期刊	MOLECULAR BIOSYSTEMS
ISSN	1742-206X
卷号	7 期号:5 页码:1441-1452
摘要	Alzheimer's disease (AD) generally results in neuronal loss due to protein dysfunction in various brain regions. Genome-wide data have provided new opportunities to analyze the underlying mechanisms of AD. Here, we present a novel network-based systems biology framework to identify and analyze differentially activated pathways by integrating human protein-protein interaction data and gene expression profile data in six brain regions. Specifically, we propose a new scoring system by ranking the edges associated with AD. Then, an edge expansion algorithm is designed to identify the dysfunctional pathways implicated in AD pathogenesis in six brain regions respectively. The analyses of the similarities and differences of these dysfunctional pathways provide insights into understanding the dynamics of AD progression in six brain regions from a network perspective, which will further shed light on the pathogenesis of AD.
DOI	10.1039/c0mb00325e
语种	英语
资助项目	SIBS from CAS[2009CSP002] ; CAS[KSCX2-EW-R-01] ; CAS[kjcs-yw-s7] ; NSFC[61072149] ; NSFC[91029301] ; NSFC[10801131] ; NSFC[60873205] ; SRF for ROCS, SEM ; Shanghai Key Laboratory of Intelligent Information Processing[IIPL-2010-008]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000289367200008
出版者	ROYAL SOC CHEMISTRY
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/11690
专题	应用数学研究所
通讯作者	Chen, Luonan
作者单位	1.Chinese Acad Sci, Key Lab Syst Biol, SIBS Novo Nordisk Translat Res Ctr PreDiabet, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 3.Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Sci, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,et al. Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients[J]. MOLECULAR BIOSYSTEMS,2011,7(5):1441-1452.
APA	Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,Xia, Weiming,&Chen, Luonan.(2011).Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients.MOLECULAR BIOSYSTEMS,7(5),1441-1452.
MLA	Liu, Zhi-Ping,et al."Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients".MOLECULAR BIOSYSTEMS 7.5(2011):1441-1452.