KMS Of Academy of mathematics and systems sciences, CAS
Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients | |
Liu, Zhi-Ping1; Wang, Yong2; Zhang, Xiang-Sun2; Xia, Weiming3; Chen, Luonan1 | |
2011 | |
发表期刊 | MOLECULAR BIOSYSTEMS |
ISSN | 1742-206X |
卷号 | 7期号:5页码:1441-1452 |
摘要 | Alzheimer's disease (AD) generally results in neuronal loss due to protein dysfunction in various brain regions. Genome-wide data have provided new opportunities to analyze the underlying mechanisms of AD. Here, we present a novel network-based systems biology framework to identify and analyze differentially activated pathways by integrating human protein-protein interaction data and gene expression profile data in six brain regions. Specifically, we propose a new scoring system by ranking the edges associated with AD. Then, an edge expansion algorithm is designed to identify the dysfunctional pathways implicated in AD pathogenesis in six brain regions respectively. The analyses of the similarities and differences of these dysfunctional pathways provide insights into understanding the dynamics of AD progression in six brain regions from a network perspective, which will further shed light on the pathogenesis of AD. |
DOI | 10.1039/c0mb00325e |
语种 | 英语 |
资助项目 | SIBS from CAS[2009CSP002] ; CAS[KSCX2-EW-R-01] ; CAS[kjcs-yw-s7] ; NSFC[61072149] ; NSFC[91029301] ; NSFC[10801131] ; NSFC[60873205] ; SRF for ROCS, SEM ; Shanghai Key Laboratory of Intelligent Information Processing[IIPL-2010-008] |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000289367200008 |
出版者 | ROYAL SOC CHEMISTRY |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.amss.ac.cn/handle/2S8OKBNM/11690 |
专题 | 应用数学研究所 |
通讯作者 | Chen, Luonan |
作者单位 | 1.Chinese Acad Sci, Key Lab Syst Biol, SIBS Novo Nordisk Translat Res Ctr PreDiabet, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 3.Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Sci, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,et al. Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients[J]. MOLECULAR BIOSYSTEMS,2011,7(5):1441-1452. |
APA | Liu, Zhi-Ping,Wang, Yong,Zhang, Xiang-Sun,Xia, Weiming,&Chen, Luonan.(2011).Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients.MOLECULAR BIOSYSTEMS,7(5),1441-1452. |
MLA | Liu, Zhi-Ping,et al."Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients".MOLECULAR BIOSYSTEMS 7.5(2011):1441-1452. |
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