Semiparametric Transformation Models with Time-Varying Coefficients for Recurrent and Terminal Events

doi:10.1111/j.1541-0420.2010.01458.x

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	Semiparametric Transformation Models with Time-Varying Coefficients for Recurrent and Terminal Events
	Zhao, Xingqiu 1; Zhou, Jie 2; Sun, Liuquan2
	2011-06-01
发表期刊	BIOMETRICS
ISSN	0006-341X
卷号	67 期号:2 页码:404-414
摘要	In this article, we propose a family of semiparametric transformation models with time-varying coefficients for recurrent event data in the presence of a terminal event such as death. The new model offers great flexibility in formulating the effects of covariates on the mean functions of the recurrent events among survivors at a given time. For the inference on the proposed models, a class of estimating equations is developed and asymptotic properties of the resulting estimators are established. In addition, a lack-of-fit test is provided for assessing the adequacy of the model, and some tests are presented for investigating whether or not covariate effects vary with time. The finite-sample behavior of the proposed methods is examined through Monte Carlo simulation studies, and an application to a bladder cancer study is also illustrated.
关键词	Counting process Estimating equation Marginal model Model checking Recurrent events Terminal event Time-varying coefficients
DOI	10.1111/j.1541-0420.2010.01458.x
语种	英语
资助项目	AMSS-PolyU Joint Research Institute ; Research Grant Council of Hong Kong ; National Natural Science Foundation of China[10731010] ; National Natural Science Foundation of China[10971015] ; National Natural Science Foundation of China[10721101] ; National Basic Research Program of China (973 Program)[2007CB814902] ; Key Laboratory of RCSDS, CAS[2008DP173182]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology ; Mathematics
WOS类目	Biology ; Mathematical & Computational Biology ; Statistics & Probability
WOS记录号	WOS:000292504000008
出版者	WILEY-BLACKWELL
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/11581
专题	应用数学研究所
通讯作者	Zhao, Xingqiu
作者单位	1.Hong Kong Polytech Univ, Dept Appl Math, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Appl Math, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xingqiu,Zhou, Jie,Sun, Liuquan. Semiparametric Transformation Models with Time-Varying Coefficients for Recurrent and Terminal Events[J]. BIOMETRICS,2011,67(2):404-414.
APA	Zhao, Xingqiu,Zhou, Jie,&Sun, Liuquan.(2011).Semiparametric Transformation Models with Time-Varying Coefficients for Recurrent and Terminal Events.BIOMETRICS,67(2),404-414.
MLA	Zhao, Xingqiu,et al."Semiparametric Transformation Models with Time-Varying Coefficients for Recurrent and Terminal Events".BIOMETRICS 67.2(2011):404-414.