Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones

doi:10.1158/1055-9965.EPI-09-0973

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	Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones
	Meyer, Tamra E.1; O'Brien, Thomas G.2; Andreotti, Gabriella 1; Yu, Kai 1; Li, Qizhai1,3 ; Gao, Yu-Tang 5; Rashid, Asif 4; Shen, Ming-Chang 6; Wang, Bing-Sheng 7; Han, Tian-Quan 8; Zhang, Bai-He 9; Niwa, Shelley 10; Fraumeni, Joseph F., Jr.1; Hsing, Ann W.1
	2010-03-01
发表期刊	CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
ISSN	1055-9965
卷号	19 期号:3 页码:787-793
摘要	Biliary tract cancers, encompassing cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater, are rare but highly fatal. Gallstones represent the major risk factor for biliary tract cancer, and share with gallbladder cancer a female predominance and an association with reproductive factors and obesity. Although estrogens have been implicated in earlier studies of gallbladder cancer, there are no data on the role of androgens. Because intracellular androgen activity is mediated through the androgen receptor (AR), we examined associations between AR CAG repeat length [(CAG)(n)] and the risk of biliary tract cancers and stones in a population-based study of 331 incident cancer cases, 837 gallstone cases, and 750 controls from Shanghai, China, where the incidence rates for biliary tract cancer are rising sharply. Men with (CAG)(n) >24 had a significant 2-fold risk of gallbladder cancer [odds ratio (OR), 2.00; 95% confidence interval (CI), 1.07-3.73], relative to those with (CAG)(n) <= 22. In contrast, women with (CAG)(n) >24 had reduced gallbladder cancer isk (OR, 0.69; 95% CI, 0.43-1.09) relative to those with (CAG)(n) <= 22; P interaction sex = 0.01, which was most pronounced for women ages 68 to 74 (OR, 0.48; 95% CI, 0.25-0.93; P interaction age = 0.02). No associations were found for bile duct cancer or gallstones. Reasons for the heterogeneity of genetic effects by gender and age are unclear but may reflect an interplay between AR and the levels of androgen as well as estrogen in men and older women. Further studies are needed to confirm these findings and clarify the mechanisms involved. Cancer Epidemiol Biomarkers Prev; 19(3); 787-93. (C) 2010 AACR.
DOI	10.1158/1055-9965.EPI-09-0973
语种	英语
资助项目	NIH ; National Cancer Institute, NIH[N01-CO-12400]
WOS研究方向	Oncology ; Public, Environmental & Occupational Health
WOS类目	Oncology ; Public, Environmental & Occupational Health
WOS记录号	WOS:000278475300019
出版者	AMER ASSOC CANCER RESEARCH
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/10981
专题	系统科学研究所
通讯作者	Meyer, Tamra E.
作者单位	1.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA 2.Lankenau Inst Med Res, Wynnewood, PA USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 4.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA 5.Shanghai Canc Inst, Shanghai 200433, Peoples R China 6.Shanghai Tumor Hosp, Shanghai, Peoples R China 7.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China 8.Shanghai Med Univ 2, Ruijin Hosp, Dept Surg, Shanghai, Peoples R China 9.Second Mil Med Univ, Inst Oriental Hepatobiliary Surg, Shanghai, Peoples R China 10.WESTAT Corp, Rockville, MD 20850 USA
推荐引用方式 GB/T 7714	Meyer, Tamra E.,O'Brien, Thomas G.,Andreotti, Gabriella,et al. Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2010,19(3):787-793.
APA	Meyer, Tamra E..,O'Brien, Thomas G..,Andreotti, Gabriella.,Yu, Kai.,Li, Qizhai.,...&Hsing, Ann W..(2010).Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,19(3),787-793.
MLA	Meyer, Tamra E.,et al."Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 19.3(2010):787-793.