Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer

doi:10.1158/0008-5472.CAN-10-1078

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	Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer
	Koutros, Stella 1; Freeman, Laura E. Beane ; Berndt, Sonja I.; Andreotti, Gabriella ; Lubin, Jay H.; Sandler, Dale P.2; Hoppin, Jane A.2; Yu, Kai ; Li, Qizhai3 ; Burdette, Laura A.4; Yuenger, Jeffrey 4; Yeager, Meredith 4; Alavanja, Michael C. R.
	2010-11-15
发表期刊	CANCER RESEARCH
ISSN	0008-5472
卷号	70 期号:22 页码:9224-9233
摘要	Genome-wide association studies have identified 8q24 region variants as risk factors for prostate cancer. In the Agricultural Health Study, a prospective study of licensed pesticide applicators, we observed increased prostate cancer risk with specific pesticide use among those with a family history of prostate cancer. Thus, we evaluated the interaction among pesticide use, 8q24 variants, and prostate cancer risk. The authors estimated odds ratios (OR) and 95% confidence intervals (95% CI) for interactions among 211 8q24 variants, 49 pesticides, and prostate cancer risk in 776 cases and 1,444 controls. The ORs for a previously identified variant, rs4242382, and prostate cancer increased significantly (P < 0.05) with exposure to the organophosphate insecticide fonofos, after correction for multiple testing, with per allele ORnonexposed of 1.17 (95% CI, 0.93-1.48), per allele ORlow of 1.30 (95% CI, 0.75-2.27), and per allele ORhigh of 4.46 (95% CI, 2.17-9.17; P-interaction = 0.002, adjusted P-interaction = 0.02). A similar effect modification was observed for three other organophosphate insecticides (coumaphos, terbufos, and phorate) and one pyrethroid insecticide (permethrin). Among ever users of fonofos, subjects with three or four risk alleles at rs7837328 and rs4242382 had approximately three times the risk of prostate cancer (OR, 3.14; 95% CI, 1.41-7.00) compared with subjects who had zero risk alleles and never used fonofos. We observed a significant interaction among variants on chromosome 8q24, pesticide use, and risk of prostate cancer. Insecticides, particularly organophosphates, were the strongest modifiers of risk, although the biological mechanism is unclear. This is the first report of effect modification between 8q24 and an environmental exposure on prostate cancer risk. Cancer Res; 70(22); 9224-33. (C) 2010 AACR.
DOI	10.1158/0008-5472.CAN-10-1078
语种	英语
资助项目	NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics[Z01CP010119] ; National Institute of Environmental Health Sciences[Z01ES049030]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000284213300028
出版者	AMER ASSOC CANCER RESEARCH
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/9384
专题	系统科学研究所
通讯作者	Koutros, Stella
作者单位	1.NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA 2.Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 4.NCI, Core Genotyping Facil, Adv Technol Program, Frederick, MD 21701 USA
推荐引用方式 GB/T 7714	Koutros, Stella,Freeman, Laura E. Beane,Berndt, Sonja I.,et al. Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer[J]. CANCER RESEARCH,2010,70(22):9224-9233.
APA	Koutros, Stella.,Freeman, Laura E. Beane.,Berndt, Sonja I..,Andreotti, Gabriella.,Lubin, Jay H..,...&Alavanja, Michael C. R..(2010).Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer.CANCER RESEARCH,70(22),9224-9233.
MLA	Koutros, Stella,et al."Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer".CANCER RESEARCH 70.22(2010):9224-9233.