KMS Of Academy of mathematics and systems sciences, CAS
| A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma | |
Landi, Maria Teresa1; Chatterjee, Nilanjan1; Yu, Kai1; Goldin, Lynn R.1; Goldstein, Alisa M.1; Rotunno, Melissa1; Mirabello, Lisa1; Jacobs, Kevin1; Wheeler, William2; Yeager, Meredith1; Bergen, Andrew W.3; Li, Qizhai1,4 ; Consonni, Dario5,6; Pesatori, Angela C.5,6; Wacholder, Sholom1; Thun, Michael7; Diver, Ryan7; Oken, Martin8; Virtamo, Jarmo9; Albanes, Demetrius1; Wang, Zhaoming1; Burdette, Laurie1; Doheny, Kimberly F.10; Pugh, Elizabeth W.10; Laurie, Cathy11; Brennan, Paul12; Hung, Rayjean13; Gaborieau, Valerie12; McKay, James D.12; Lathrop, Mark14; McLaughlin, John13; Wang, Ying13; Tsao, Ming-Sound15; Spitz, Margaret R.16; Wang, Yufei17; Krokan, Hans18; Vatten, Lars18; Skorpen, Frank18; Arnesen, Egil19; Benhamou, Simone14,20; Bouchard, Christine21; Metsapalu, Andres22,23; Vooder, Tonu22,23; Nelis, Mari22,23; Vaelk, Kristian22,23; Field, John K.24; Chen, Chu25; Goodman, Gary25; Sulem, Patrick26; Thorleifsson, Gudmar26; Rafnar, Thorunn26; Eisen, Timothy27; Sauter, Wiebke28; Rosenberger, Albert31; Bickeboeller, Heike31; Risch, Angela32; Chang-Claude, Jenny32; Wichmann, H. Erich28,29,30; Stefansson, Kari26; Houlston, Richard17; Amos, Christopher I.16; Fraumeni, Joseph F., Jr.1; Savage, Sharon A.1; Bertazzi, Pier Alberto5,6; Tucker, Margaret A.1; Chanock, Stephen1; Caporaso, Neil E.1
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| 2009-11-13 | |
| Source Publication | AMERICAN JOURNAL OF HUMAN GENETICS
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| ISSN | 0002-9297 |
| Volume | 85Issue:5Pages:679-691 |
| Abstract | Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma. |
| DOI | 10.1016/j.ajhg.2009.09.012 |
| Language | 英语 |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000271916500014 |
| Publisher | CELL PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/9137 |
| Collection | 系统科学研究所 |
| Corresponding Author | Landi, Maria Teresa |
| Affiliation | 1.NCI, Div Canc Epidemiol, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA 2.Informat Management Serv Inc, Rockville, MD 20852 USA 3.SRI Int, Ctr Hlth Sci, Mol Genet program, Menlo Pk, CA 94025 USA 4.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China 5.Osped Maggiore Policlin Mangiagalli & Regina Elen, Fdn Ist Ricevero & Cura Carattere Sci, Epidemiol Unit, I-20122 Milan, Italy 6.Univ Milan, Dept Occupat & Environm Hlth, I-20122 Milan, Italy 7.Amer Canc Soc Epidemiol & Surveillance Res, Atlanta, GA 30301 USA 8.Univ Minnesota, Hubert H Humphrey Canc Ctr, Minneapolis, MN 55455 USA 9.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00280, Finland 10.Johns Hopkins Univ, Sch Med, Inst Med Genet, Ctr Inherited Dis Res, Baltimore, MD 21224 USA 11.Univ Washington, Dept Biostat, Seattle, WA 98195 USA 12.Int Agcy Res Canc, F-69372 Lyon, France 13.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Samuel Lunenfeld Res Inst, Toronto, ON M5T 3L9, Canada 14.Fdn Jean Dausset, Ctr Etud Polymorphisme Humain, F-75010 Paris, France 15.Princess Margaret Hosp, Univ Hlth Network, Dept Pathol, Toronto, ON M5T 3L9, Canada 16.Univ Texas Houston, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA 17.Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England 18.Norwegian Univ Sci & Technol, Fac Med, N-7489 Trondheim, Norway 19.Univ Tromso, Dept Community Med, N-9037 Tromso, Norway 20.INSERM, F-75010 Paris, France 21.Geneva Canc Registry, CH-1205 Geneva, Switzerland 22.Univ Tartu, Inst Mol & Cell Biol, Estonian Bioctr, EE-51010 Tartu, Estonia 23.Univ Tartu, Estonian Genome Project, Estonian Bioctr, EE-51010 Tartu, Estonia 24.Univ Liverpool, Canc Res Ctr, Roy Castle Lung Canc Res Program, Liverpool L3 97A, Merseyside, England 25.Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA 26.DeCODE Genet, IS-101 Reykjavik, Iceland 27.Univ Cambridge, Dept Oncol, Cambridge CB2 2RE, England 28.German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Epidemiol, D-85764 Neuherberg, Germany 29.Univ Munich, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, D-81377 Munich, Germany 30.Univ Munich, Klinikum Grosshadern, D-81377 Munich, Germany 31.Univ Gottingen, Dept Genet Epidemiol, Sch Med, D-37073 Gottingen, Germany 32.German Canc Res Ctr, Div Epigenom & Canc Risk Factors, D-69120 Heidelberg, Germany |
| Recommended Citation GB/T 7714 | Landi, Maria Teresa,Chatterjee, Nilanjan,Yu, Kai,et al. A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2009,85(5):679-691. |
| APA | Landi, Maria Teresa.,Chatterjee, Nilanjan.,Yu, Kai.,Goldin, Lynn R..,Goldstein, Alisa M..,...&Caporaso, Neil E..(2009).A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.AMERICAN JOURNAL OF HUMAN GENETICS,85(5),679-691. |
| MLA | Landi, Maria Teresa,et al."A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma".AMERICAN JOURNAL OF HUMAN GENETICS 85.5(2009):679-691. |
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