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A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma
Landi, Maria Teresa1; Chatterjee, Nilanjan1; Yu, Kai1; Goldin, Lynn R.1; Goldstein, Alisa M.1; Rotunno, Melissa1; Mirabello, Lisa1; Jacobs, Kevin1; Wheeler, William2; Yeager, Meredith1; Bergen, Andrew W.3; Li, Qizhai1,4; Consonni, Dario5,6; Pesatori, Angela C.5,6; Wacholder, Sholom1; Thun, Michael7; Diver, Ryan7; Oken, Martin8; Virtamo, Jarmo9; Albanes, Demetrius1; Wang, Zhaoming1; Burdette, Laurie1; Doheny, Kimberly F.10; Pugh, Elizabeth W.10; Laurie, Cathy11; Brennan, Paul12; Hung, Rayjean13; Gaborieau, Valerie12; McKay, James D.12; Lathrop, Mark14; McLaughlin, John13; Wang, Ying13; Tsao, Ming-Sound15; Spitz, Margaret R.16; Wang, Yufei17; Krokan, Hans18; Vatten, Lars18; Skorpen, Frank18; Arnesen, Egil19; Benhamou, Simone14,20; Bouchard, Christine21; Metsapalu, Andres22,23; Vooder, Tonu22,23; Nelis, Mari22,23; Vaelk, Kristian22,23; Field, John K.24; Chen, Chu25; Goodman, Gary25; Sulem, Patrick26; Thorleifsson, Gudmar26; Rafnar, Thorunn26; Eisen, Timothy27; Sauter, Wiebke28; Rosenberger, Albert31; Bickeboeller, Heike31; Risch, Angela32; Chang-Claude, Jenny32; Wichmann, H. Erich28,29,30; Stefansson, Kari26; Houlston, Richard17; Amos, Christopher I.16; Fraumeni, Joseph F., Jr.1; Savage, Sharon A.1; Bertazzi, Pier Alberto5,6; Tucker, Margaret A.1; Chanock, Stephen1; Caporaso, Neil E.1
AbstractThree genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma.
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000271916500014
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Document Type期刊论文
Corresponding AuthorLandi, Maria Teresa
Affiliation1.NCI, Div Canc Epidemiol, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
2.Informat Management Serv Inc, Rockville, MD 20852 USA
3.SRI Int, Ctr Hlth Sci, Mol Genet program, Menlo Pk, CA 94025 USA
4.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China
5.Osped Maggiore Policlin Mangiagalli & Regina Elen, Fdn Ist Ricevero & Cura Carattere Sci, Epidemiol Unit, I-20122 Milan, Italy
6.Univ Milan, Dept Occupat & Environm Hlth, I-20122 Milan, Italy
7.Amer Canc Soc Epidemiol & Surveillance Res, Atlanta, GA 30301 USA
8.Univ Minnesota, Hubert H Humphrey Canc Ctr, Minneapolis, MN 55455 USA
9.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00280, Finland
10.Johns Hopkins Univ, Sch Med, Inst Med Genet, Ctr Inherited Dis Res, Baltimore, MD 21224 USA
11.Univ Washington, Dept Biostat, Seattle, WA 98195 USA
12.Int Agcy Res Canc, F-69372 Lyon, France
13.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Samuel Lunenfeld Res Inst, Toronto, ON M5T 3L9, Canada
14.Fdn Jean Dausset, Ctr Etud Polymorphisme Humain, F-75010 Paris, France
15.Princess Margaret Hosp, Univ Hlth Network, Dept Pathol, Toronto, ON M5T 3L9, Canada
16.Univ Texas Houston, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
17.Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England
18.Norwegian Univ Sci & Technol, Fac Med, N-7489 Trondheim, Norway
19.Univ Tromso, Dept Community Med, N-9037 Tromso, Norway
20.INSERM, F-75010 Paris, France
21.Geneva Canc Registry, CH-1205 Geneva, Switzerland
22.Univ Tartu, Inst Mol & Cell Biol, Estonian Bioctr, EE-51010 Tartu, Estonia
23.Univ Tartu, Estonian Genome Project, Estonian Bioctr, EE-51010 Tartu, Estonia
24.Univ Liverpool, Canc Res Ctr, Roy Castle Lung Canc Res Program, Liverpool L3 97A, Merseyside, England
25.Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA
26.DeCODE Genet, IS-101 Reykjavik, Iceland
27.Univ Cambridge, Dept Oncol, Cambridge CB2 2RE, England
28.German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Epidemiol, D-85764 Neuherberg, Germany
29.Univ Munich, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, D-81377 Munich, Germany
30.Univ Munich, Klinikum Grosshadern, D-81377 Munich, Germany
31.Univ Gottingen, Dept Genet Epidemiol, Sch Med, D-37073 Gottingen, Germany
32.German Canc Res Ctr, Div Epigenom & Canc Risk Factors, D-69120 Heidelberg, Germany
Recommended Citation
GB/T 7714
Landi, Maria Teresa,Chatterjee, Nilanjan,Yu, Kai,et al. A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2009,85(5):679-691.
APA Landi, Maria Teresa.,Chatterjee, Nilanjan.,Yu, Kai.,Goldin, Lynn R..,Goldstein, Alisa M..,...&Caporaso, Neil E..(2009).A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.AMERICAN JOURNAL OF HUMAN GENETICS,85(5),679-691.
MLA Landi, Maria Teresa,et al."A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma".AMERICAN JOURNAL OF HUMAN GENETICS 85.5(2009):679-691.
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