Cross-platform method for identifying candidate network biomarkers for prostate cancer

doi:10.1049/iet-syb.2008.0168

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	Cross-platform method for identifying candidate network biomarkers for prostate cancer
	Jin, G.1; Zhou, X.1; Cui, K.1; Zhang, X. -S.2 ; Chen, L.3; Wong, S. T. C.1
	2009-11-01
发表期刊	IET SYSTEMS BIOLOGY
ISSN	1751-8849
卷号	3 期号:6 页码:505-512
摘要	Discovering biomarkers using mass spectrometry (MS) and microarray expression profiles is a promising strategy in molecular diagnosis. Here, the authors proposed a new pipeline for biomarker discovery that integrates disease information for proteins and genes, expression profiles in both genomic and proteomic levels, and protein-protein interactions (PPIs) to discover high confidence network biomarkers. Using this pipeline, a total of 474 molecules (genes and proteins) related to prostate cancer were identified and a prostate-cancer-related network (PCRN) was derived from the integrative information. Thus, a set of candidate network biomarkers were identified from multiple expression profiles composed by eight microarray datasets and one proteomics dataset. The network biomarkers with PPIs can accurately distinguish the prostate patients from the normal ones, which potentially provide more reliable hits of biomarker candidates than conventional biomarker discovery methods.
DOI	10.1049/iet-syb.2008.0168
语种	英语
WOS研究方向	Cell Biology ; Mathematical & Computational Biology
WOS类目	Cell Biology ; Mathematical & Computational Biology
WOS记录号	WOS:000272502400008
出版者	INST ENGINEERING TECHNOLOGY-IET
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/7494
专题	应用数学研究所
通讯作者	Jin, G.
作者单位	1.Methodist Hosp, Med Syst Biol Lab, Ctr Bioinformat & Biotechnol, Res Inst,Weill Cornell Med Coll, Houston, TX 77030 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 3.Osaka Sangyo Univ, Dept Elect Engn, Osaka 5748530, Japan
推荐引用方式 GB/T 7714	Jin, G.,Zhou, X.,Cui, K.,et al. Cross-platform method for identifying candidate network biomarkers for prostate cancer[J]. IET SYSTEMS BIOLOGY,2009,3(6):505-512.
APA	Jin, G.,Zhou, X.,Cui, K.,Zhang, X. -S.,Chen, L.,&Wong, S. T. C..(2009).Cross-platform method for identifying candidate network biomarkers for prostate cancer.IET SYSTEMS BIOLOGY,3(6),505-512.
MLA	Jin, G.,et al."Cross-platform method for identifying candidate network biomarkers for prostate cancer".IET SYSTEMS BIOLOGY 3.6(2009):505-512.