Identifying differentially expressed pathways via a mixed integer linear programming model

doi:10.1049/iet-syb.2008.0155

	Identifying differentially expressed pathways via a mixed integer linear programming model
	Qiu, Y-Q.1,2; Zhang, S.1,2 ; Zhang, X. -S.1 ; Chen, L.3
	2009-11-01
发表期刊	IET SYSTEMS BIOLOGY
ISSN	1751-8849
卷号	3 期号:6 页码:475-486
摘要	The identification of genes and pathways involved in biological processes is a central problem in systems biology. Recent microarray technologies and other high-throughput experiments provide information which sheds light on this problem. In this article, the authors propose a new computational method to detect active pathways, or identify differentially expressed pathways via integration of gene expression and interactomic data in a sophisticated and efficient manner. Specifically, by using signal-to-noise ratio to measure the differentially expressed level of networks, this problem is formulated as a mixed integer linear programming problem (MILP). The results on yeast and human data demonstrate that the proposed method is more accurate and robust than existing approaches.
DOI	10.1049/iet-syb.2008.0155
语种	英语
WOS研究方向	Cell Biology ; Mathematical & Computational Biology
WOS类目	Cell Biology ; Mathematical & Computational Biology
WOS记录号	WOS:000272502400005
出版者	INST ENGINEERING TECHNOLOGY-IET
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/7041
专题	计算数学与科学工程计算研究所应用数学研究所
通讯作者	Qiu, Y-Q.
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Osaka Sangyo Univ, Dept Elect Engn & Elect, Osaka 5748530, Japan
推荐引用方式 GB/T 7714	Qiu, Y-Q.,Zhang, S.,Zhang, X. -S.,et al. Identifying differentially expressed pathways via a mixed integer linear programming model[J]. IET SYSTEMS BIOLOGY,2009,3(6):475-486.
APA	Qiu, Y-Q.,Zhang, S.,Zhang, X. -S.,&Chen, L..(2009).Identifying differentially expressed pathways via a mixed integer linear programming model.IET SYSTEMS BIOLOGY,3(6),475-486.
MLA	Qiu, Y-Q.,et al."Identifying differentially expressed pathways via a mixed integer linear programming model".IET SYSTEMS BIOLOGY 3.6(2009):475-486.