Bridging protein local structures and protein functions

doi:10.1007/s00726-008-0088-8

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	Bridging protein local structures and protein functions
	Liu, Zhi-Ping 2; Wu, Ling-Yun2 ; Wang, Yong2 ; Zhang, Xiang-Sun2 ; Chen, Luonan 1
	2008-10-01
发表期刊	AMINO ACIDS
ISSN	0939-4451
卷号	35 期号:3 页码:627-650
摘要	One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based methods, which are able to identify locally structural motifs and reveal their relationship with protein functions. These methods include computational tools to identify the structural motifs and reveal the strong relationship between these pre-computed local structures and protein functions. We also discuss remaining problems and possible directions for this exciting and challenging area.
关键词	functional genomics functional motifs local structures protein function prediction
DOI	10.1007/s00726-008-0088-8
语种	英语
资助项目	National Natural Science Foundation of China (NSFC)[10631070] ; National Natural Science Foundation of China (NSFC)[60503004] ; Ministry of Science and Technology, China[5039052006CB] ; NSFC-JSPS[10711140116]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000258833500013
出版者	SPRINGER
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/6318
专题	应用数学研究所
通讯作者	Chen, Luonan
作者单位	1.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,et al. Bridging protein local structures and protein functions[J]. AMINO ACIDS,2008,35(3):627-650.
APA	Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2008).Bridging protein local structures and protein functions.AMINO ACIDS,35(3),627-650.
MLA	Liu, Zhi-Ping,et al."Bridging protein local structures and protein functions".AMINO ACIDS 35.3(2008):627-650.