KMS Of Academy of mathematics and systems sciences, CAS
| Bridging protein local structures and protein functions | |
Liu, Zhi-Ping2; Wu, Ling-Yun2 ; Wang, Yong2; Zhang, Xiang-Sun2; Chen, Luonan1
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| 2008-10-01 | |
| Source Publication | AMINO ACIDS
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| ISSN | 0939-4451 |
| Volume | 35Issue:3Pages:627-650 |
| Abstract | One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based methods, which are able to identify locally structural motifs and reveal their relationship with protein functions. These methods include computational tools to identify the structural motifs and reveal the strong relationship between these pre-computed local structures and protein functions. We also discuss remaining problems and possible directions for this exciting and challenging area. |
| Keyword | functional genomics functional motifs local structures protein function prediction |
| DOI | 10.1007/s00726-008-0088-8 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China (NSFC)[10631070] ; National Natural Science Foundation of China (NSFC)[60503004] ; Ministry of Science and Technology, China[5039052006CB] ; NSFC-JSPS[10711140116] |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000258833500013 |
| Publisher | SPRINGER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/6318 |
| Collection | 应用数学研究所 |
| Corresponding Author | Chen, Luonan |
| Affiliation | 1.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,et al. Bridging protein local structures and protein functions[J]. AMINO ACIDS,2008,35(3):627-650. |
| APA | Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2008).Bridging protein local structures and protein functions.AMINO ACIDS,35(3),627-650. |
| MLA | Liu, Zhi-Ping,et al."Bridging protein local structures and protein functions".AMINO ACIDS 35.3(2008):627-650. |
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