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Bridging protein local structures and protein functions
Liu, Zhi-Ping2; Wu, Ling-Yun2; Wang, Yong2; Zhang, Xiang-Sun2; Chen, Luonan1
Source PublicationAMINO ACIDS
AbstractOne of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based methods, which are able to identify locally structural motifs and reveal their relationship with protein functions. These methods include computational tools to identify the structural motifs and reveal the strong relationship between these pre-computed local structures and protein functions. We also discuss remaining problems and possible directions for this exciting and challenging area.
Keywordfunctional genomics functional motifs local structures protein function prediction
Funding ProjectNational Natural Science Foundation of China (NSFC)[10631070] ; National Natural Science Foundation of China (NSFC)[60503004] ; Ministry of Science and Technology, China[5039052006CB] ; NSFC-JSPS[10711140116]
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000258833500013
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Document Type期刊论文
Corresponding AuthorChen, Luonan
Affiliation1.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,et al. Bridging protein local structures and protein functions[J]. AMINO ACIDS,2008,35(3):627-650.
APA Liu, Zhi-Ping,Wu, Ling-Yun,Wang, Yong,Zhang, Xiang-Sun,&Chen, Luonan.(2008).Bridging protein local structures and protein functions.AMINO ACIDS,35(3),627-650.
MLA Liu, Zhi-Ping,et al."Bridging protein local structures and protein functions".AMINO ACIDS 35.3(2008):627-650.
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