Spatial transcriptomics shows moxibustion promotes hippocampus astrocyte and neuron interaction

doi:10.1016/j.lfs.2022.121052

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	Spatial transcriptomics shows moxibustion promotes hippocampus astrocyte and neuron interaction
	Zhang, Ning 1,2; Shen, Yuan 1; Zhu, Weikang 3; Li, Chenyu 1; Liu, Shuqing 1; Li, Hongying 1; Wang, Yong3 ; Wang, Junmeng 1; Zhang, Qun 1; Sun, Jiayi 4; Xie, Lushuang 5; Yu, Shuguang 1; Wu, Qiaofeng 1
	2022-12-01
发表期刊	LIFE SCIENCES
ISSN	0024-3205
卷号	310 页码:13
摘要	Aims: Alzheimer's disease (AD) is a common and irreversible neurodegenerative disease accompanied by extensive synaptic loss. Previous studies found that moxibustion had good therapeutic effects on AD. We here investigated whether moxibustion could alleviate the cognitive impairment of AD by promoting the "astrocyte-neuron" interaction and enhancing synaptic plasticity.Materials and methods: Moxibustion treatment was administrated to Baihui (GV20) and Yongquan (KI1) in APP/ PS1 mice. We first evaluated the behavior of APP/PS1 mice with Morris water maze test, and observed the synaptic structure before and after moxibustion intervention. Then, the transcriptome characteristics (TC) and "astrocyte-neuron" interaction were evaluated by spatial transcriptomics (ST). CD38 and its ligand Pecam1, one of the energy shuttle pathways between neurons and astrocytes, were also be detected.Key findings: The results supported that moxibustion increased learning and memory ability and synaptic structure. ST showed that the TC were more similar between the moxibustion and control groups. Moxibustion enhanced the number of ligand -receptor pairs between astrocytes and neurons. And the score of interaction intensity and the proportion of interaction were also increased. Meanwhile, the energy of astrocytes and neurons was significantly altered. Additionally, moxibustion could significantly improve the function of CD38 and its ligand Pecam1 which were previously reported having the function of transporting mitochondria from astrocytes to neurons, and then providing energy for neurons.Significance: Our study provides new evidences for the use of moxibustion to increase the "astrocyte -neuron" interaction thus to enhance synaptic plasticity of APP/PS1 mice.
关键词	Moxibustion Alzheimer's disease Spatial transcriptomics Synaptic plasticity ?Astrocyte-neuron? interaction
DOI	10.1016/j.lfs.2022.121052
收录类别	SCI
语种	英语
资助项目	National Key Research and Devel-opment Program of China[2019YFC1709001] ; National Natural Science Foundation of China[81873386] ; National Natural Science Foundation of China[81704160] ; National Natural Science Foundation of China[82174512] ; National Natural Science Foundation of China[82174511] ; Innovation Team and Talents Cultivation Program of Na-tional Administration of Traditional Chinese Medicine[ZYYCXTD-D-202003] ; Fund of Science and Technology Department of Sichuan Province, China[2021ZYD0081]
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:000886100600001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/60605
专题	应用数学研究所
通讯作者	Xie, Lushuang; Yu, Shuguang; Wu, Qiaofeng
作者单位	1.Chengdu Univ Tradit Chinese Med, Acupuncture & Moxibust Sch, Chengdu 610075, Peoples R China 2.Shaanxi Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Xianyang 712046, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, CEMS,NCMIS,MDIS, Beijing 100000, Peoples R China 4.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 610075, Peoples R China 5.Chengdu Univ Tradit Chinese Med, Coll Basic Med, Chengdu 610075, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ning,Shen, Yuan,Zhu, Weikang,et al. Spatial transcriptomics shows moxibustion promotes hippocampus astrocyte and neuron interaction[J]. LIFE SCIENCES,2022,310:13.
APA	Zhang, Ning.,Shen, Yuan.,Zhu, Weikang.,Li, Chenyu.,Liu, Shuqing.,...&Wu, Qiaofeng.(2022).Spatial transcriptomics shows moxibustion promotes hippocampus astrocyte and neuron interaction.LIFE SCIENCES,310,13.
MLA	Zhang, Ning,et al."Spatial transcriptomics shows moxibustion promotes hippocampus astrocyte and neuron interaction".LIFE SCIENCES 310(2022):13.