KMS Of Academy of mathematics and systems sciences, CAS
| Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity | |
Shi, Xiaohan1; Li, Yunguang2,3; Yuan, Qiuyue4,5; Tang, Shijie2,3; Guo, Shiwei1; Zhang, Yehan1; He, Juan2,3; Zhang, Xiaoyu2,3; Han, Ming2,3; Liu, Zhuang1,3; Zhu, Yiqin2; Gao, Suizhi1; Wang, Huan1; Xu, Xiongfei1; Zheng, Kailian1; Jing, Wei1; Chen, Luonan2,6,7,8; Wang, Yong4,5,6,7 ; Jin, Gang1; Gao, Dong2,9
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| 2022-04-21 | |
| Source Publication | NATURE COMMUNICATIONS
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| Volume | 13Issue:1Pages:16 |
| Abstract | Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular subtypes of pancreatic cancer, predict numerous chromatin accessibility peaks associated with gene regulatory networks, discover regulatory noncoding mutations with potential as cancer drivers, and reveal the chromatin accessibility signatures associated with drug sensitivity. These results not only provide the chromatin accessibility atlas of pancreatic cancer but also suggest a systematic approach to comprehensively understand the gene regulatory network of pancreatic cancer in order to advance diagnosis and potential personalized medicine applications. The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes. |
| DOI | 10.1038/s41467-022-29857-6 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020905] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB38040400] ; National key research and development program of China[2017YFA0505500] ; National key research and development program of China[2020YFA0509000] ; National key research and development program of China[2020YFA0712402] ; Basic Frontier Science Research Program of Chinese Academy of Sciences[ZDBS-LY-SM015] ; National Natural Science Foundation of China[32125013] ; National Natural Science Foundation of China[81830054] ; National Natural Science Foundation of China[81772723] ; National Natural Science Foundation of China[31930022] ; National Natural Science Foundation of China[31771476] ; National Natural Science Foundation of China[12131020] ; National Natural Science Foundation of China[12026608] ; National Natural Science Foundation of China[82002559] ; National Natural Science Foundation of China[82172589] ; National Natural Science Foundation of China[81972913] ; National Natural Science Foundation of China[82172712] ; National Natural Science Foundation of China[12025107] ; National Natural Science Foundation of China[11871463] ; National Natural Science Foundation of China[61621003] ; Shanghai Science and Technology Committee[21XD1424200] ; Shanghai Science and Technology Committee[21ZR1470100] ; Shanghai Science and Technology Committee[20ZR1456500] ; Shanghai Science and Technology Committee[20511101200] ; JST Moonshot RD[JPMJMS2021] ; Shanghai ShenKang hospital development center[SHDC2020CR2001A] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000785003900011 |
| Publisher | NATURE PORTFOLIO |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/60379 |
| Collection | 应用数学研究所 |
| Corresponding Author | Chen, Luonan; Wang, Yong; Jin, Gang; Gao, Dong |
| Affiliation | 1.Naval Med Univ, Changhai Hosp, Dept Hepatobiliary Pancreat Surg, Mil Med Univ 2, Shanghai, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Shanghai Key Lab Mol Andr, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, HCMS,NCMIS,CEMS, Beijing 100080, Peoples R China 5.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 7.Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou, Peoples R China 8.Guangdong Inst Intelligence Sci & Technol, Zhuhai 519031, Guangdong, Peoples R China 9.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China |
| Recommended Citation GB/T 7714 | Shi, Xiaohan,Li, Yunguang,Yuan, Qiuyue,et al. Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity[J]. NATURE COMMUNICATIONS,2022,13(1):16. |
| APA | Shi, Xiaohan.,Li, Yunguang.,Yuan, Qiuyue.,Tang, Shijie.,Guo, Shiwei.,...&Gao, Dong.(2022).Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.NATURE COMMUNICATIONS,13(1),16. |
| MLA | Shi, Xiaohan,et al."Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity".NATURE COMMUNICATIONS 13.1(2022):16. |
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