KMS Of Academy of mathematics and systems sciences, CAS
| Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy | |
| Gao, Hao1; Liu, Jiulong2; Lin, Yuting1; Gan, Gregory N.1; Pratx, Guillem3; Wang, Fen1; Langen, Katja4; Bradley, Jeffrey D.4; Rotondo, Ronny L.1; Li, Harold H.1; Chen, Ronald C.1 | |
| 2021-12-07 | |
| Source Publication | MEDICAL PHYSICS
 |
| ISSN | 0094-2405 |
| Pages | 12 |
| Abstract | Purpose Compared to CONV-RT (with conventional dose rate), FLASH-RT (with ultra-high dose rate) can provide biological dose sparing for organs-at-risk (OARs) via the so-called FLASH effect, in addition to physical dose sparing. However, the FLASH effect only occurs, when both dose and dose rate meet certain minimum thresholds. This work will develop a simultaneous dose and dose rate optimization (SDDRO) method accounting for both FLASH dose and dose rate constraints during treatment planning for pencil-beam-scanning proton therapy. Methods SDDRO optimizes the FLASH effect (specific to FLASH-RT) as well as the dose distribution (similar to CONV-RT). The nonlinear dose rate constraint is linearized, and the reformulated optimization problem is efficiently solved via iterative convex relaxation powered by alternating direction method of multipliers. To resolve and quantify the generic tradeoff of FLASH-RT between FLASH and dose optimization, we propose the use of FLASH effective dose based on dose modifying factor (DMF) owing to the FLASH effect. Results FLASH-RT via transmission beams (TB) (IMPT-TB or SDDRO) and CONV-RT via Bragg peaks (BP) (IMPT-BP) were evaluated for clinical prostate, lung, head-and-neck (HN), and brain cases. Despite the use of TB, which is generally suboptimal to BP for normal tissue sparing, FLASH-RT via SDDRO considerably reduced FLASH effective dose for high-dose OAR adjacent to the target. For example, in the lung SBRT case, the max esophageal dose constraint 27 Gy was only met by SDDRO (24.8 Gy), compared to IMPT-BP (35.3 Gy) or IMPT-TB (36.6 Gy); in the brain SRS case, the brain constraint V12Gy <= 15cc was also only met by SDDRO (13.7cc), compared to IMPT-BP (43.9cc) or IMPT-TB (18.4cc). In addition, SDDRO substantially improved the FLASH coverage from IMPT-TB, e.g., an increase from 37.2% to 67.1% for lung, from 39.1% to 58.3% for prostate, from 65.4% to 82.1% for HN, from 50.8% to 73.3% for the brain. Conclusions Both FLASH dose and dose rate constraints are incorporated into SDDRO for FLASH-RT that jointly optimizes the FLASH effect and physical dose distribution. FLASH effective dose via FLASH DMF is introduced to reconcile the tradeoff between physical dose sparing and FLASH sparing, and quantify the net effective gain from CONV-RT to FLASH-RT. |
| Keyword | dose rate optimization FLASH dose modifying factor IMPT proton therapy |
| DOI | 10.1002/mp.15356 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | NIH[R37CA250921] |
| WOS Research Area | Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000727552400001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/59656 |
| Collection | 中国科学院数学与系统科学研究院 |
| Corresponding Author | Gao, Hao |
| Affiliation | 1.Univ Kansas, Med Ctr, Dept Radiat Oncol, Kansas City, KS 66103 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Inst Computat Math & Sci Engn Comp, LSEC, Beijing, Peoples R China 3.Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA 4.Emory Univ, Dept Radiat Oncol, Atlanta, GA 30322 USA |
| Recommended Citation GB/T 7714 | Gao, Hao,Liu, Jiulong,Lin, Yuting,et al. Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy[J]. MEDICAL PHYSICS,2021:12. |
| APA | Gao, Hao.,Liu, Jiulong.,Lin, Yuting.,Gan, Gregory N..,Pratx, Guillem.,...&Chen, Ronald C..(2021).Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy.MEDICAL PHYSICS,12. |
| MLA | Gao, Hao,et al."Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy".MEDICAL PHYSICS (2021):12. |
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