KMS Of Academy of mathematics and systems sciences, CAS
| Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age | |
Fang, Fengqin1,2; Cao, Wenqiang1,2,3; Zhu, Weikang4,5; Lam, Nora6,7; Li, Lingjie8,9,10; Gaddam, Sadhana8,9; Wang, Yong4,5 ; Kim, Chulwoo1,2; Lambert, Simon1,2; Zhang, Huimin1,2,3; Hu, Bin1,2; Farber, Donna L.7,11; Weyand, Cornelia M.1,2,3; Goronzy, Jorg J.1,2,3
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| 2021-11-09 | |
| Source Publication | CELL REPORTS
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| ISSN | 2211-1247 |
| Volume | 37Issue:6Pages:24 |
| Abstract | Memory T cells exhibit considerable diversity that determines their ability to be protective. Here, we examine whether changes in T cell heterogeneity contribute to the age-associated failure of immune memory. By screening for age-dependent T cell-surface markers, we identify CD4 and CD8 memory T cell subsets that are unrelated to previously defined subsets of central and effector memory cells. Memory T cells expressing the ecto-5'-nucleotidase CD73 constitute a functionally distinct subset of memory T cells that declines with age. They resemble long-lived, polyfunctional memory cells but are also poised to display effector functions and to develop into cells resembling tissue-resident memory T cells (TRMs). Upstream regulators of differential chromatin accessibility and transcriptomes include transcription factors that facilitate CD73 expression and regulate TRM differentiation. CD73 is not just a surrogate marker of these regulatory networks but is directly involved in T cell survival. |
| DOI | 10.1016/j.celrep.2021.109981 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Institutes of Health[R01 AR042527] ; National Institutes of Health[R01 HL117913] ; National Institutes of Health[R01 AI108906] ; National Institutes of Health[R01 HL142068] ; National Institutes of Health[P01 HL129941] ; National Institutes of Health[P01 AI106697] ; National Institutes of Health[R01 AI108891] ; National Institutes of Health[R01 AG045779] ; National Institutes of Health[U19 AI057266] ; National Institutes of Health[R01 AI129191] ; National Natural Science Foundation of China (NSFC)[11871463] ; National Natural Science Foundation of China (NSFC)[12025107] ; National Natural Science Foundation of China (NSFC)[61621003] ; NSF GRFP ; US Department of Veterans Affairs ; Palo Alto Veterans Institute for Research |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell Biology |
| WOS ID | WOS:000718275500005 |
| Publisher | CELL PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/59569 |
| Collection | 应用数学研究所 |
| Corresponding Author | Goronzy, Jorg J. |
| Affiliation | 1.Stanford Univ, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA 2.Palo Alto Vet Adm Healthcare Syst, Dept Med, Palo Alto, CA 94304 USA 3.Mayo Clin, Coll Med & Sci, Dept Immunol, Rochester, MN 55905 USA 4.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, CEMS,NCMIS,HCMS, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 6.Columbia Univ, Irving Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA 7.Columbia Univ, Irving Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA 8.Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA 9.Stanford Univ, Sch Med, Dept Dermatol, Stanford, CA 94305 USA 10.Shanghai Jiao Tong Univ, Sch Med, Dept Histoembryol Genet & Dev Biol, Shanghai Key Lab Reprod Med, Shanghai 200025, Peoples R China 11.Columbia Univ, Irving Med Ctr, Dept Surg, New York, NY 10032 USA |
| Recommended Citation GB/T 7714 | Fang, Fengqin,Cao, Wenqiang,Zhu, Weikang,et al. Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age[J]. CELL REPORTS,2021,37(6):24. |
| APA | Fang, Fengqin.,Cao, Wenqiang.,Zhu, Weikang.,Lam, Nora.,Li, Lingjie.,...&Goronzy, Jorg J..(2021).Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age.CELL REPORTS,37(6),24. |
| MLA | Fang, Fengqin,et al."Article The cell-surface 5 '-nucleotidase CD73 defines a functional T memory cell subset that declines with age".CELL REPORTS 37.6(2021):24. |
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