Quasi-steady-state laws in enzyme kinetics

doi:10.1021/jp077597q

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	Quasi-steady-state laws in enzyme kinetics
	Li, Banghe1 ; Shen, Yuefeng ; Li, Bo
	2008-03-20
发表期刊	JOURNAL OF PHYSICAL CHEMISTRY A
ISSN	1089-5639
卷号	112 期号:11 页码:2311-2321
摘要	To understand how enzymes work is essential for understanding life processes. And, in enzyme kinetics, a fundamental assumption is the so-called Quasi-Steady-State Assumption, which has the history of more than 80 years and has been proven very fruitful in analyzing the equations of enzyme kinetics. Many experimental results and numerical results have shown the validity of the assumption. So, an important problem is if it is always true. If it is always true, then it should be a law, not only an assumption. In this paper, we prove mathematically rigorously that it is indeed always true. Hence, it is a law, and we name it the Quasi-Steady-State Law. Actually, more precisely, we have two Quasi-Steady-State Laws. In one of them quasi-steady state means that the concentration of the enzyme-substrate complex remains approximately constant, and in the other it means that the change rate of the concentration of enzyme-substrate complex is extremely tiny.
DOI	10.1021/jp077597q
语种	英语
WOS研究方向	Chemistry ; Physics
WOS类目	Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
WOS记录号	WOS:000253946100019
出版者	AMER CHEMICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/5898
专题	系统科学研究所
通讯作者	Li, Banghe
作者单位	1.Chinese Acad Sci, Ctr Bioinformat, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Math Mechanizat, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Li, Banghe,Shen, Yuefeng,Li, Bo. Quasi-steady-state laws in enzyme kinetics[J]. JOURNAL OF PHYSICAL CHEMISTRY A,2008,112(11):2311-2321.
APA	Li, Banghe,Shen, Yuefeng,&Li, Bo.(2008).Quasi-steady-state laws in enzyme kinetics.JOURNAL OF PHYSICAL CHEMISTRY A,112(11),2311-2321.
MLA	Li, Banghe,et al."Quasi-steady-state laws in enzyme kinetics".JOURNAL OF PHYSICAL CHEMISTRY A 112.11(2008):2311-2321.