The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events

doi:10.1021/pr8002886

CSpace > 应用数学研究所

	The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events
	Jin, Guangxu 3; Zhou, Xiaobo 1; Wang, Honghui 5; Zhao, Hong ; Cui, Kemi ; Zhang, Xiang-Sun3 ; Chen, Luonan 6; Hazen, Stanley L.7; Li, King 4; Wong, Stephen T. C.
	2008-09-01
发表期刊	JOURNAL OF PROTEOME RESEARCH
ISSN	1535-3893
卷号	7 期号:9 页码:4013-4021
摘要	The mass spectrometry (MS) technology in clinical proteomics is very promising for discovery of new biomarkers for diseases management. To overcome the obstacles of data noises in MS analysis, we proposed a new approach of knowledge-integrated biomarker discovery using data from Major Adverse Cardiac Events (MACE) patients. We first built up a cardiovascular-related network based on protein information coming from protein annotations in Uniprot, protein-protein interaction (PPI), and signal transduction database. Distinct from the previous machine learning methods in MS data processing, we then used statistical methods to discover biomarkers in cardiovascular-related network. Through the tradeoff between known protein information and data noises in mass spectrometry data, we finally could firmly identify those high-confident biomarkers. Most importantly, aided by protein-protein interaction network, that is, cardiovascular-related network, we proposed a new type of biomarkers, that is, network biomarkers, composed of a set of proteins and the interactions among them. The candidate network biomarkers can classify the two groups of patients more accurately than current single ones without consideration of biological molecular interaction.
关键词	proteomics mass spectrometry MACE network biomarker cross validation systems biology
DOI	10.1021/pr8002886
语种	英语
资助项目	Methodist Research Institute, Cornell University ; The Methodist Hospital ; NIH[R01LM08696] ; NIH[R01LM009161] ; NIH[R01AG028928]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemical Research Methods
WOS记录号	WOS:000259015500036
出版者	AMER CHEMICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/5318
专题	应用数学研究所
通讯作者	Zhou, Xiaobo
作者单位	1.Methodist Hosp, Inst Res, Ctr Biotechnol & Informat, Houston, TX 77030 USA 2.Cornell Univ, Houston, TX 77030 USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 4.Methodist Hosp, Dept Radiol, Houston, TX 77030 USA 5.Natl Inst Hlth, Ctr Clin, Bethesda, MD 20892 USA 6.Osaka Sangyo Univ, Dept Elect Engn, Osaka 5748530, Japan 7.CCF, Ctr Cardiovasc Diagnost & Prevent, Cleveland, OH 44195 USA
推荐引用方式 GB/T 7714	Jin, Guangxu,Zhou, Xiaobo,Wang, Honghui,et al. The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events[J]. JOURNAL OF PROTEOME RESEARCH,2008,7(9):4013-4021.
APA	Jin, Guangxu.,Zhou, Xiaobo.,Wang, Honghui.,Zhao, Hong.,Cui, Kemi.,...&Wong, Stephen T. C..(2008).The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events.JOURNAL OF PROTEOME RESEARCH,7(9),4013-4021.
MLA	Jin, Guangxu,et al."The knowledge-integrated network biomarkers discovery for Major Adverse Cardiac Events".JOURNAL OF PROTEOME RESEARCH 7.9(2008):4013-4021.