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Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard
Wu, Mixia1; Zhang, Xiaoyu1; Zhang, Wei2; Zhang, Xu1; Liu, Aiyi3
2020-11-27
发表期刊STATISTICS IN MEDICINE
ISSN0277-6715
页码25
摘要This article concerns evaluating the effectiveness of a continuous diagnostic biomarker against a continuous gold standard that is measured with error. Extending the work of Obuchowski (2005, 2016), Wu et al (2016) suggested an accuracy index and proposed an estimator for the index with error-prone standard when the reliability coefficient is known. Combining with additional measurements (without measurement errors) on the continuous gold standard collected from some subjects, this article proposes two adaptive estimators of the accuracy index when the reliability coefficient is unknown, and further establish the consistency and asymptotic normality of these estimators. Simulation studies are conducted to compare various estimators. Data from an intervention trial on glycemic control among children with type 1 diabetes are used to illustrate the proposed methods.
关键词adaptive estimation additive errors asymptotic normality biomarkers diagnostic accuracy measurement errors reliability coefficient
DOI10.1002/sim.8818
收录类别SCI
语种英语
资助项目Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
WOS研究方向Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
WOS类目Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability
WOS记录号WOS:000593002800001
出版者WILEY
引用统计
文献类型期刊论文
条目标识符http://ir.amss.ac.cn/handle/2S8OKBNM/52505
专题中国科学院数学与系统科学研究院
通讯作者Liu, Aiyi
作者单位1.Beijing Univ Technol, Coll Stat & Data Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing, Peoples R China
3.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA
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Wu, Mixia,Zhang, Xiaoyu,Zhang, Wei,et al. Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard[J]. STATISTICS IN MEDICINE,2020:25.
APA Wu, Mixia,Zhang, Xiaoyu,Zhang, Wei,Zhang, Xu,&Liu, Aiyi.(2020).Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard.STATISTICS IN MEDICINE,25.
MLA Wu, Mixia,et al."Error-corrected estimation of a diagnostic accuracy index of a biomarker against a continuous gold standard".STATISTICS IN MEDICINE (2020):25.
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