Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study

doi:10.1007/s00784-019-03189-0

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	Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study
	Lin, Xiaoyu 1; Wu, Xiaoshan 1; Gomaa, Aly 2; Chen, Jie 1; Wu, Limeng 1; Xie, Xiaoyue 3,4; Hu, Yaqin 1; Jiang, Canhua 1
	2020-09-01
发表期刊	CLINICAL ORAL INVESTIGATIONS
ISSN	1432-6981
卷号	24 期号:9 页码:3147-3155
摘要	Objective Chewing betel quid (CBQ) is popular in Southeast Asia, resulting in a high incidence of oral squamous cell carcinoma (OSCC). The incidence of multiple primary oral cancer (MPOC) has gradually increased and has become one of the main causes of OSCC treatment failure. However, it is unclear whether the high incidence of MPOC is also correlated with the habit of CBQ. Materials and methods In this retrospective study, 915 OSCC patients were enrolled. MPOC incidence and characteristics were analyzed. CBQ and other risk factors for MPOC were investigated by chi-squared test and logistic stepwise regression analysis. Results Among 915 patients, 15 were diagnosed with synchronous MPOC. After follow-up, 60 of 915 patients developed a second or third primary lesion site and were diagnosed with metachronous MPOC. The remaining 840 patients were then diagnosed with single primary oral cancer (SPOC). The cumulative incidence of MPOC in all OSCC patients was 8.2%. CBQ and the related oral submucous fibrosis (OSF) were found to be independent risk factors of MPOC (P < 0.001). Both MPOC and SPOC patients with a CBQ habit were much younger than those who did not have a CBQ habit (P < 0.001). The buccal mucosa was the most common primary occurrence site (35.9%) in MPOC cases, and almost all MPOC patients with buccal cancer had previously suffered from OSF (88.9%). Conclusion CBQ and CBQ-related OSF, for the first time, are identified as the independent risk factors of MPOC. Prevention and treatment of OSF as well as cessation of CBQ are expected to become new approaches to reduce the incidence of MPOC.
关键词	Oral squamous cell carcinoma Multiple primary oral cancer Chewing betel quid Risk factor
DOI	10.1007/s00784-019-03189-0
收录类别	SCI
语种	英语
WOS研究方向	Dentistry, Oral Surgery & Medicine
WOS类目	Dentistry, Oral Surgery & Medicine
WOS记录号	WOS:000559810400020
出版者	SPRINGER HEIDELBERG
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/51977
专题	中国科学院数学与系统科学研究院
通讯作者	Jiang, Canhua
作者单位	1.Cent South Univ, Xiangya Hosp, Dept Oral & Maxillofacial Surg, Changsha 410008, Hunan, Peoples R China 2.Menia Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Al Minya 11435, Egypt 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lin, Xiaoyu,Wu, Xiaoshan,Gomaa, Aly,et al. Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study[J]. CLINICAL ORAL INVESTIGATIONS,2020,24(9):3147-3155.
APA	Lin, Xiaoyu.,Wu, Xiaoshan.,Gomaa, Aly.,Chen, Jie.,Wu, Limeng.,...&Jiang, Canhua.(2020).Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study.CLINICAL ORAL INVESTIGATIONS,24(9),3147-3155.
MLA	Lin, Xiaoyu,et al."Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study".CLINICAL ORAL INVESTIGATIONS 24.9(2020):3147-3155.