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Group analysis of distance matrices
Wang, Jinjuan1,2; Li, Jialu3; Xiong, Wenjun4; Li, Qizhai1,2
2020-06-21
发表期刊GENETIC EPIDEMIOLOGY
ISSN0741-0395
页码9
摘要Distance-based regression model has become a powerful approach to identifying phenotypic associations in many fields. It is found to be particularly useful for high-dimensional biological and genetic data with proper distance or similarity measures being available. The pseudoFstatistic used in this model accumulates information and is effective when the signals, that is the variations represented by the eigenvalues of the similarity matrix, scatter evenly along the eigenvectors of the similarity matrix. However, it might lose power for the uneven signals. To deal with this issue, we propose a group analysis on the variations of signals along the eigenvalues of the similarity matrix and take the maximum among them. The new procedure can automatically choose an optimal grouping point on some given thresholds and thus can improve the power evidence. Extensive computer simulations and applications to a prostate cancer data and an aging human brain data illustrate the effectiveness of the proposed method.
关键词distance-based regression eigenvalue decomposition pseudoFtest statistic
DOI10.1002/gepi.22329
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[11722113] ; Natural Science Foundation of Beijing Municipality[Z180006]
WOS研究方向Genetics & Heredity ; Mathematical & Computational Biology
WOS类目Genetics & Heredity ; Mathematical & Computational Biology
WOS记录号WOS:000541436300001
出版者WILEY
引用统计
文献类型期刊论文
条目标识符http://ir.amss.ac.cn/handle/2S8OKBNM/51691
专题中国科学院数学与系统科学研究院
通讯作者Li, Qizhai
作者单位1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Beijing Inst Technol, Sch Math & Stat, Beijing, Peoples R China
4.Guangxi Normal Univ, Guangxi, Peoples R China
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GB/T 7714
Wang, Jinjuan,Li, Jialu,Xiong, Wenjun,et al. Group analysis of distance matrices[J]. GENETIC EPIDEMIOLOGY,2020:9.
APA Wang, Jinjuan,Li, Jialu,Xiong, Wenjun,&Li, Qizhai.(2020).Group analysis of distance matrices.GENETIC EPIDEMIOLOGY,9.
MLA Wang, Jinjuan,et al."Group analysis of distance matrices".GENETIC EPIDEMIOLOGY (2020):9.
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