KMS Of Academy of mathematics and systems sciences, CAS
| Group analysis of distance matrices | |
| Wang, Jinjuan1,2; Li, Jialu3; Xiong, Wenjun4; Li, Qizhai1,2 | |
| 2020-06-21 | |
| 发表期刊 | GENETIC EPIDEMIOLOGY
 |
| ISSN | 0741-0395 |
| 页码 | 9 |
| 摘要 | Distance-based regression model has become a powerful approach to identifying phenotypic associations in many fields. It is found to be particularly useful for high-dimensional biological and genetic data with proper distance or similarity measures being available. The pseudoFstatistic used in this model accumulates information and is effective when the signals, that is the variations represented by the eigenvalues of the similarity matrix, scatter evenly along the eigenvectors of the similarity matrix. However, it might lose power for the uneven signals. To deal with this issue, we propose a group analysis on the variations of signals along the eigenvalues of the similarity matrix and take the maximum among them. The new procedure can automatically choose an optimal grouping point on some given thresholds and thus can improve the power evidence. Extensive computer simulations and applications to a prostate cancer data and an aging human brain data illustrate the effectiveness of the proposed method. |
| 关键词 | distance-based regression eigenvalue decomposition pseudoFtest statistic |
| DOI | 10.1002/gepi.22329 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[11722113] ; Natural Science Foundation of Beijing Municipality[Z180006] |
| WOS研究方向 | Genetics & Heredity ; Mathematical & Computational Biology |
| WOS类目 | Genetics & Heredity ; Mathematical & Computational Biology |
| WOS记录号 | WOS:000541436300001 |
| 出版者 | WILEY |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.amss.ac.cn/handle/2S8OKBNM/51691 |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Li, Qizhai |
| 作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Beijing Inst Technol, Sch Math & Stat, Beijing, Peoples R China 4.Guangxi Normal Univ, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jinjuan,Li, Jialu,Xiong, Wenjun,et al. Group analysis of distance matrices[J]. GENETIC EPIDEMIOLOGY,2020:9. |
| APA | Wang, Jinjuan,Li, Jialu,Xiong, Wenjun,&Li, Qizhai.(2020).Group analysis of distance matrices.GENETIC EPIDEMIOLOGY,9. |
| MLA | Wang, Jinjuan,et al."Group analysis of distance matrices".GENETIC EPIDEMIOLOGY (2020):9. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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