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Prevalence and Risk Factors of White Matter Lesions in Tibetan Patients Without Acute Stroke
Jin, Haiqiang1; Ding, Zhijie2; Lian, Siqing1; Zhao, Yuhua2; He, Shihua2; Zhou, Lewei3; Zhuoga, Cidan2; Wang, Huali4; Xu, Jun5; Du, Ailian6; Yan, Guiying3; Sun, Yongan1
2020
发表期刊STROKE
ISSN0039-2499
卷号51期号:1页码:149-153
摘要Background and Purpose- Studies on the prevalence and risk factors of white matter lesions (WMLs) in Tibetans living at high altitudes are scarce. We conducted this study to determine the prevalence and risks of WMLs in Tibetan patients without or with nonacute stroke. Methods- We undertook a retrospective analysis of medical records of patients treated at the People's Hospital of Tibetan Autonomous Region and identified a total of 301 Tibetan patients without acute stroke. WML severity was graded by the Fazekas Scale. We assessed the overall and age-specific prevalence of WMLs and analyzed associations between WMLs and related factors with univariate and multivariate methods. Results- Of the 301 patients, 87 (28.9%) had peripheral vertigo, 83 (27.3%) had primary headache, 52 (17.3%) had a history of stroke, 36 (12.0%) had an anxiety disorder, 29 (9.6%) had epilepsy, 12 (4.0%) had infections of the central nervous system, and 3 (1.0%) had undetermined diseases. WMLs were present in 245 (81.4%) patients, and 54 (17.9%) were younger than 40 years. Univariate analysis showed that age, history of cerebral infarction, hypertension, the thickness of the common carotid artery intima, and plaque within the intracarotid artery were related risks for WMLs. Ordered logistic analysis showed that age, history of cerebral ischemic stroke, hypertension, male sex, and atrial fibrillation were associated with WML severity. Conclusions- Risk factors for WMLs appear similar for Tibetans residing at high altitudes and individuals living in the plains. Further investigations are needed to determine whether Tibetans residing at high altitudes have a higher burden of WMLs than inhabitants of the plains.
关键词atrial fibrillation carotid artery cerebral infarction hypertension white matter
DOI10.1161/STROKEAHA.119.027115
收录类别SCI
语种英语
资助项目State Key Program of National Natural Science of China[11631014]
WOS研究方向Neurosciences & Neurology ; Cardiovascular System & Cardiology
WOS类目Clinical Neurology ; Peripheral Vascular Disease
WOS记录号WOS:000504225600036
出版者LIPPINCOTT WILLIAMS & WILKINS
引用统计
文献类型期刊论文
条目标识符http://ir.amss.ac.cn/handle/2S8OKBNM/50455
专题应用数学研究所
通讯作者Sun, Yongan
作者单位1.Peking Univ, Dept Neurol, Hosp 1, Beijing, Peoples R China
2.Peoples Hosp Tibet Autonomous Reg, Dept Neurol, Lhasa, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
4.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing Dementia Key Lab,Natl Clin Res Ctr Mental, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tian Tan Hosp, China Natl Clin Res Ctr Neurol Dis NCRC ND, Dept Cognit Neurol, Beijing, Peoples R China
6.Shanghai Jiao Tong Univ, Tongren Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China
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GB/T 7714
Jin, Haiqiang,Ding, Zhijie,Lian, Siqing,et al. Prevalence and Risk Factors of White Matter Lesions in Tibetan Patients Without Acute Stroke[J]. STROKE,2020,51(1):149-153.
APA Jin, Haiqiang.,Ding, Zhijie.,Lian, Siqing.,Zhao, Yuhua.,He, Shihua.,...&Sun, Yongan.(2020).Prevalence and Risk Factors of White Matter Lesions in Tibetan Patients Without Acute Stroke.STROKE,51(1),149-153.
MLA Jin, Haiqiang,et al."Prevalence and Risk Factors of White Matter Lesions in Tibetan Patients Without Acute Stroke".STROKE 51.1(2020):149-153.
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