Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model

doi:10.1002/bimj.200610294

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	Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model
	Liang, Hua ; Zou, Guohua
	2007-06-01
发表期刊	BIOMETRICAL JOURNAL
ISSN	0323-3847
卷号	49 期号:3 页码:406-415
摘要	In this article we propose to use a semiparametric mixed-effects model based on an exploratory analysis of clinical trial data for a study of the relation between virologic responses and immunologic markers such as CD4+ and CD8 counts, and host-specific factors in AIDS clinical trials. The regression spline technique, used for inference for parameters in the model, reduces the unknown nonparametric components to parametric functions. It is simple and straightforward to implement the procedures using readily available software, and parameter inference can be developed from standard parametric models. We apply the model and the proposed method to an AIDS clinical study. Our findings indicate that viral load level is positively related to baseline viral load level, negatively related to CD4+ cell counts, but unrelated to CD8 cell counts and patient's age neither.
关键词	AIDS clinical trial HIV dynamics longitudinal data partially linear models regression splines
DOI	10.1002/bimj.200610294
语种	英语
WOS研究方向	Mathematical & Computational Biology ; Mathematics
WOS类目	Mathematical & Computational Biology ; Statistics & Probability
WOS记录号	WOS:000247715800007
出版者	WILEY-V C H VERLAG GMBH
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/4722
专题	中国科学院数学与系统科学研究院
通讯作者	Liang, Hua
作者单位	1.Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Liang, Hua,Zou, Guohua. Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model[J]. BIOMETRICAL JOURNAL,2007,49(3):406-415.
APA	Liang, Hua,&Zou, Guohua.(2007).Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model.BIOMETRICAL JOURNAL,49(3),406-415.
MLA	Liang, Hua,et al."Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model".BIOMETRICAL JOURNAL 49.3(2007):406-415.