Flexible design for following up positive findings

doi:10.1086/520678

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	Flexible design for following up positive findings
	Yu, Kai ; Chatterjee, Nilanjan ; Wheeler, William ; Li, Qizhai ; Wang, Sophia ; Rothman, Nathaniel ; Wacholder, Sholom
	2007-09-01
发表期刊	AMERICAN JOURNAL OF HUMAN GENETICS
ISSN	0002-9297
卷号	81 期号:3 页码:540-551
摘要	As more population-based studies suggest associations between genetic variants and disease risk, there is a need to improve the design of follow-up studies (stage II) in independent samples to confirm evidence of association observed at the initial stage (stage I). We propose to use flexible designs developed for randomized clinical trials in the calculation of sample size for follow-up studies. We apply a bootstrap procedure to correct the effect of regression to the mean, also called "winner's curse," resulting from choosing to follow up the markers with the strongest associations. We show how the results from stage I can improve sample size calculations for stage II adaptively. Despite the adaptive use of stage I data, the proposed method maintains the nominal global type I error for final analyses on the basis of either pure replication with the stage II data only or a joint analysis using information from both stages. Simulation studies show that sample-size calculations accounting for the impact of regression to the mean with the bootstrap procedure are more appropriate than is the conventional method. We also find that, in the context of flexible design, the joint analysis is generally more powerful than the replication analysis.
DOI	10.1086/520678
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000249128200010
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/4710
专题	中国科学院数学与系统科学研究院
通讯作者	Yu, Kai
作者单位	1.NCI, Div Canc Epidemiol & Genet, Rockville, MD USA 2.Informat Management Serv Inc, Rockville, MD USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yu, Kai,Chatterjee, Nilanjan,Wheeler, William,et al. Flexible design for following up positive findings[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2007,81(3):540-551.
APA	Yu, Kai.,Chatterjee, Nilanjan.,Wheeler, William.,Li, Qizhai.,Wang, Sophia.,...&Wacholder, Sholom.(2007).Flexible design for following up positive findings.AMERICAN JOURNAL OF HUMAN GENETICS,81(3),540-551.
MLA	Yu, Kai,et al."Flexible design for following up positive findings".AMERICAN JOURNAL OF HUMAN GENETICS 81.3(2007):540-551.