characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina

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	characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina
	Chen Haixia 1; He Li 2; Cai Chao 3; Liu Jingyi 1; Jia Junnan 3; Ma Liang 4; Huang Hairong 3; Wang Lixia 5; Ni Xumin 6; Gao Jimin 1; Li Weimin 3
	2018
发表期刊	sciencechinalifesciences
ISSN	1674-7305
卷号	61 期号:6 页码:651
摘要	The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education] ; [Fundamental Research Funds for the Central Universities] ; [China Postdoctoral Science Foundation]
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/45547
专题	中国科学院数学与系统科学研究院
作者单位	1.温州医科大学 2.中国科学院数学与系统科学研究院 3.首都医科大学 4.中国科学院北京基因组研究所 5.National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention 6.北京交通大学
推荐引用方式 GB/T 7714	Chen Haixia,He Li,Cai Chao,et al. characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina[J]. sciencechinalifesciences,2018,61(6):651.
APA	Chen Haixia.,He Li.,Cai Chao.,Liu Jingyi.,Jia Junnan.,...&Li Weimin.(2018).characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina.sciencechinalifesciences,61(6),651.
MLA	Chen Haixia,et al."characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina".sciencechinalifesciences 61.6(2018):651.