Chen Haixia1; He Li2; Cai Chao3; Liu Jingyi1; Jia Junnan3; Ma Liang4; Huang Hairong3; Wang Lixia5; Ni Xumin6; Gao Jimin1; Li Weimin3
Source Publicationsciencechinalifesciences
AbstractThe genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.
Funding Project[National Natural Science Foundation of China] ; [Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education] ; [Fundamental Research Funds for the Central Universities] ; [China Postdoctoral Science Foundation]
Document Type期刊论文
5.National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention
Recommended Citation
GB/T 7714
Chen Haixia,He Li,Cai Chao,et al. characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina[J]. sciencechinalifesciences,2018,61(6):651.
APA Chen Haixia.,He Li.,Cai Chao.,Liu Jingyi.,Jia Junnan.,...&Li Weimin.(2018).characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina.sciencechinalifesciences,61(6),651.
MLA Chen Haixia,et al."characteristicsofdistributionofmycobacteriumtuberculosislineagesinchina".sciencechinalifesciences 61.6(2018):651.
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