Quasi-physical algorithm for protein folding in an off-lattice model

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	Quasi-physical algorithm for protein folding in an off-lattice model
	Lu Zhi-Peng ; Huang Wen-Qi ; Shi He
	2007
发表期刊	COMMUNICATIONS IN THEORETICAL PHYSICS
ISSN	0253-6102
卷号	47 期号:1 页码:181-185
摘要	we study a three-dimensional off-lattice protein folding model, which involves two species of residues interacting through Lennard-Jones potentials. By incorporating an extra energy contribution into the original potential function, we replace the original constrained problem with an unconstrained minimization of a mixed potential function. As such an efficient quasi-physical algorithm for solving the protein folding problem is presented. We apply the proposed algorithm to sequences with up to 55 residues and compare the computational results with the putative lowest energy found by several of the most famous algorithms, showing the advantages of our method. The dynamic behavior of the quasi-physical algorithm is also discussed.
关键词	quasi-physical algorithm conjugate gradient method protein folding off-lattice model
语种	英语
WOS研究方向	Physics
WOS类目	Physics, Multidisciplinary
WOS记录号	WOS:000243764900034
出版者	INTERNATIONAL ACADEMIC PUBLISHERS LIMITED
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/4421
专题	中国科学院数学与系统科学研究院
通讯作者	Lu Zhi-Peng
作者单位	1.Huazhong Univ Sci & Technol, Sch Comp Sci & Technol, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Lu Zhi-Peng,Huang Wen-Qi,Shi He. Quasi-physical algorithm for protein folding in an off-lattice model[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2007,47(1):181-185.
APA	Lu Zhi-Peng,Huang Wen-Qi,&Shi He.(2007).Quasi-physical algorithm for protein folding in an off-lattice model.COMMUNICATIONS IN THEORETICAL PHYSICS,47(1),181-185.
MLA	Lu Zhi-Peng,et al."Quasi-physical algorithm for protein folding in an off-lattice model".COMMUNICATIONS IN THEORETICAL PHYSICS 47.1(2007):181-185.