Discovering functions and revealing mechanisms at molecular level from biological networks

doi:10.1002/pmic.200700095

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	Discovering functions and revealing mechanisms at molecular level from biological networks
	Zhang, Shihua; Jin, Guangxu ; Zhang, Xiang-Sun; Chen, Luonan
	2007-08-01
发表期刊	PROTEOMICS
ISSN	1615-9853
卷号	7 期号:16 页码:2856-2869
摘要	With the increasingly accumulated data from high-throughput technologies, study on biomolecular networks has become one of key focuses in systems biology and bioinformatics. In particular, various types of molecular networks (e.g., protein-protein interaction (PPI) network; gene regulatory network (GRN); metabolic network (MN); gene coexpression network (GCEN)). have been extensively investigated, and those studies demonstrate great potentials to discover basic functions and to reveal essential mechanisms for various biological phenomena, by understanding biological systems not at individual component level but at a system-wide level. Recent studies on networks have created very prolific researches on many aspects of living organisms. In this paper, we aim to review the recent developments on topics related to molecular networks in a comprehensive manner, with the special emphasis on the computational aspect. The contents of the survey cover global topological properties and local structural characteristics, network motifs, network comparison and query, detection of functional modules and network motifs, function prediction from network analysis, inferring molecular networks from biological data as well as representative databases and software tools.
关键词	biological network network analysis network comparison network integration protein interaction network
DOI	10.1002/pmic.200700095
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemical Research Methods ; Biochemistry & Molecular Biology
WOS记录号	WOS:000249295500014
出版者	WILEY-V C H VERLAG GMBH
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/4310
专题	应用数学研究所
通讯作者	Zhang, Xiang-Sun
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Shanghai Univ, Inst Syst Biol, Shanghai, Peoples R China 3.Osaka Sangyo Univ, Osaka, Japan 4.JST, ERATO, Aihara Complex Modelling Project, Tokyo, Japan 5.Univ Tokyo, Inst Ind Sci, Tokyo, Japan
推荐引用方式 GB/T 7714	Zhang, Shihua,Jin, Guangxu,Zhang, Xiang-Sun,et al. Discovering functions and revealing mechanisms at molecular level from biological networks[J]. PROTEOMICS,2007,7(16):2856-2869.
APA	Zhang, Shihua,Jin, Guangxu,Zhang, Xiang-Sun,&Chen, Luonan.(2007).Discovering functions and revealing mechanisms at molecular level from biological networks.PROTEOMICS,7(16),2856-2869.
MLA	Zhang, Shihua,et al."Discovering functions and revealing mechanisms at molecular level from biological networks".PROTEOMICS 7.16(2007):2856-2869.