amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation

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	amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation
	Hu Xiaonan 1; Duan Xiaogang 2; Pan Dongdong 3; Zhang Sanguo 1; Li Qizhai4
	2017
发表期刊	journalofsystemsscienceandcomplexity
ISSN	1009-6124
卷号	30 期号:1 页码:101
摘要	The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/42207
专题	系统科学研究所
作者单位	1.中国科学院大学 2.北京师范大学 3.云南大学 4.中国科学院数学与系统科学研究院
推荐引用方式 GB/T 7714	Hu Xiaonan,Duan Xiaogang,Pan Dongdong,et al. amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation[J]. journalofsystemsscienceandcomplexity,2017,30(1):101.
APA	Hu Xiaonan,Duan Xiaogang,Pan Dongdong,Zhang Sanguo,&Li Qizhai.(2017).amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation.journalofsystemsscienceandcomplexity,30(1),101.
MLA	Hu Xiaonan,et al."amodelembeddedtrendtestwithincorporatinghardyweinbergequilibriuminformation".journalofsystemsscienceandcomplexity 30.1(2017):101.