Identification of functional modules in a PPI network by clique percolation clustering

doi:10.1016/j.compbiolchem.2006.10.001

CSpace > 应用数学研究所

	Identification of functional modules in a PPI network by clique percolation clustering
	Zhang, Shihua; Ning, Xuemei ; Zhang, Xiang-Sun
	2006-12-01
发表期刊	COMPUTATIONAL BIOLOGY AND CHEMISTRY
ISSN	1476-9271
卷号	30 期号:6 页码:445-451
摘要	Large-scale experiments and data integration have provided the opportunity to systematically analyze and comprehensively understand the topology of biological networks and biochemical processes in cells. Modular architecture which encompasses groups of genes/proteins involved in elementary biological functional units is a basic form of the organization of interacting proteins. Here we apply a graph clustering algorithm based on clique percolation clustering to detect overlapping network modules of a protein-protein interaction (PPI) network. Our analysis of the yeast Sacchromyces cerevisiae suggests that most of the detected modules correspond to one or more experimentally functional modules and half of these annotated modules match well with experimentally determined protein complexes. Our method of analysis can of course be applied to protein-protein interaction data for any species and even other biological networks. (c) 2006 Elsevier Ltd. All rights reserved.
关键词	protein-protein interaction (PPI) network network clustering protein complexes functional modules clique percolation clustering
DOI	10.1016/j.compbiolchem.2006.10.001
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Computer Science
WOS类目	Biology ; Computer Science, Interdisciplinary Applications
WOS记录号	WOS:000243091500007
出版者	ELSEVIER SCI LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/3885
专题	应用数学研究所
通讯作者	Zhang, Shihua
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shihua,Ning, Xuemei,Zhang, Xiang-Sun. Identification of functional modules in a PPI network by clique percolation clustering[J]. COMPUTATIONAL BIOLOGY AND CHEMISTRY,2006,30(6):445-451.
APA	Zhang, Shihua,Ning, Xuemei,&Zhang, Xiang-Sun.(2006).Identification of functional modules in a PPI network by clique percolation clustering.COMPUTATIONAL BIOLOGY AND CHEMISTRY,30(6),445-451.
MLA	Zhang, Shihua,et al."Identification of functional modules in a PPI network by clique percolation clustering".COMPUTATIONAL BIOLOGY AND CHEMISTRY 30.6(2006):445-451.