On the sample size requirement in genetic association tests when the proportion of false positives is controlled

doi:10.1534/genetics.105.049536

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	On the sample size requirement in genetic association tests when the proportion of false positives is controlled
	Zou, GH ; Zuo, YJ
	2006
发表期刊	GENETICS
ISSN	0016-6731
卷号	172 期号:1 页码:687-691
摘要	With respect to the multiple-tests problem, recently an increasing amount of attention has been paid to control the false discovery rate (FDR), the positive false discovery rate (pFDR), and the proportion of false positives (PFP). The new approaches are generally believed to be more powerful than the classical Bonferroni one. This article focuses on the PFP approach. It demonstrates via examples in genetic association studies that the Bonferroni procedure can be more powerful than the PFP-control one and also shows the intrinsic connection between controlling the PFP and controlling the overall type I error rate. Since controlling the PFP does not necessarily lead to a desired power level, this article addresses the design issue and recommends the sample sizes that can attain the desired power levels when the PFP is controlled. The results in this article also provide rough guidance for the sample sizes to achieve the desired power levels when the FDR and especially the pFDR are controlled.
DOI	10.1534/genetics.105.049536
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000235197700058
出版者	GENETICS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/3378
专题	中国科学院数学与系统科学研究院
通讯作者	Zou, GH
作者单位	1.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48824 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zou, GH,Zuo, YJ. On the sample size requirement in genetic association tests when the proportion of false positives is controlled[J]. GENETICS,2006,172(1):687-691.
APA	Zou, GH,&Zuo, YJ.(2006).On the sample size requirement in genetic association tests when the proportion of false positives is controlled.GENETICS,172(1),687-691.
MLA	Zou, GH,et al."On the sample size requirement in genetic association tests when the proportion of false positives is controlled".GENETICS 172.1(2006):687-691.