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A much better replacement of the Michaelis-Menten equation and its application
Li, Banghe1,2; Li, Bo2; Shen, Yuefeng1
AbstractMichaelis-Menten equation is a basic equation of enzyme kinetics and gives acceptable approximations of real chemical reaction processes. Analyzing the derivation of this equation yields the fact that its good performance of approximating real reaction processes is due to Michaelis-Menten curve (8). This curve is derived from Quasi-Steady-State Assumption (QSSA), which has been proved always true and called Quasi-Steady-State Law by Banghe Li et al. [Quasi-steady state laws in enzyme kinetics, J. Phys. Chem. A 112(11) (2008) 2311-2321]. Here, we found a polynomial equation with total degree of four A(S, E) = 0 (14), which gives more accurate approximation of the reaction process in two aspects: during the quasi-steady-state of the reaction, Michaelis-Menten curve approximates the reaction well, while our equation A(S, E) = 0 gives better approximation; near the end of the reaction, our equation approaches the end of the reaction with a tangent line the same to that of the reaction process trajectory simulated by mass action, while Michaelis-Menten curve does not. In addition, our equation A(S, E) = 0 differs to Michaelis-Menten curve less than the order of 1/S-3 as S approaches +infinity. By considering the above merits of A(S, E) = 0, we suggest it as a replacement of Michaelis-Menten curve. Intuitively, this new equation is more complex and harder to understand. But, just because of its complexity, it provides more information about the rate constants than Michaelis-Menten curve does. Finally, we get a better replacement of the Michaelis-Menten equation by combing A(S, E) = 0 and the equation dP/dt = k(2)C(t).
KeywordRate constants of enzyme kinetics quasi-steady-state assumption quasi-steady-state law
Funding ProjectNational Natural Science Foundation of China[11301518]
WOS Research AreaMathematical & Computational Biology
WOS SubjectMathematical & Computational Biology
WOS IDWOS:000457466600008
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Document Type期刊论文
Corresponding AuthorLi, Banghe
Affiliation1.Chinese Acad Sci, Key Lab Math Mechanizat, Acad Math & Syst Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Banghe,Li, Bo,Shen, Yuefeng. A much better replacement of the Michaelis-Menten equation and its application[J]. INTERNATIONAL JOURNAL OF BIOMATHEMATICS,2019,12(1):22.
APA Li, Banghe,Li, Bo,&Shen, Yuefeng.(2019).A much better replacement of the Michaelis-Menten equation and its application.INTERNATIONAL JOURNAL OF BIOMATHEMATICS,12(1),22.
MLA Li, Banghe,et al."A much better replacement of the Michaelis-Menten equation and its application".INTERNATIONAL JOURNAL OF BIOMATHEMATICS 12.1(2019):22.
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