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Models and algorithms for haplotyping problem
Zhang, Xiang-Sun; Wang, Rui-Sheng; Wu, Ling-Yun; Chen, Luonan
AbstractOne of the main topics in genomics is to determine the relevance of DNA variations with some genetic disease. Single nucleotide polymorphism (SNP) is the most frequent and important form of genetic variation which involves a single DNA base. The values of a set of SNPs on a particular chromosome copy define a haplotype. Because of its importance in the studies of complex disease association, haplotyping is one of the central problems in bioinformatics. There are two classes of in silico haplotyping problems, i.e., single individual haplotyping and population haplotyping. In this review paper, we give an overview on the existing models and algorithms on this topic, report the recent. progresses from the computational viewpoint and further discuss the future research trends.
WOS Research AreaBiochemistry & Molecular Biology ; Mathematical & Computational Biology
WOS SubjectBiochemical Research Methods ; Mathematical & Computational Biology
WOS IDWOS:000244372700011
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Document Type期刊论文
Corresponding AuthorChen, Luonan
Affiliation1.Osaka Sangyo Univ, Dept Elect Engn & Elect, Osaka 5748530, Japan
2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100080, Peoples R China
3.Renmin Univ China, Sch Informat, Beijing 100872, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiang-Sun,Wang, Rui-Sheng,Wu, Ling-Yun,et al. Models and algorithms for haplotyping problem[J]. CURRENT BIOINFORMATICS,2006,1(1):105-114.
APA Zhang, Xiang-Sun,Wang, Rui-Sheng,Wu, Ling-Yun,&Chen, Luonan.(2006).Models and algorithms for haplotyping problem.CURRENT BIOINFORMATICS,1(1),105-114.
MLA Zhang, Xiang-Sun,et al."Models and algorithms for haplotyping problem".CURRENT BIOINFORMATICS 1.1(2006):105-114.
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