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Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable
Zhu, Jiayan1,2,3; Zhang, Wei4; Li, Qizhai4; Li, Zhengbang1,2; Zhu, Jiayan5,6,7; Zhang, Wei8; Li, Qizhai8; Li, Zhengbang5,6
2017-08-14
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号7期号:8006页码:10
摘要

Multiple outcomes are often collected simultaneously in biomedical fields in order to identify whether a continuous response and an ordinal response are associated with some covariates simultaneously. Here we propose a joint statistical model by the use of a latent variable underlying the ordinal response. Asymptotic results are obtained and a jointly test is proposed for testing the continuous response and the ordinal response are associated with some covariates simultaneously. Extensive simulations and real data analysis results indicate more efficient performances of the proposed method than that of the combined p-values method.

DOI10.1038/s41598-017-08371-6
语种英语
资助项目National Nature Science Foundation of China[11401240] ; National Nature Science Foundation of China[11471135] ; Chinese Academy of Sciences[XDB13040600] ; Special National Key Research and Development Plan[2016YFD0400206]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000407559100006
出版者NATURE PUBLISHING GROUP
引用统计
文献类型期刊论文
条目标识符http://ir.amss.ac.cn/handle/2S8OKBNM/26298
专题系统科学研究所
作者单位1.Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China
2.Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Hubei, Peoples R China
3.Wuhan Coll, Sch Informat & Commun, Wuhan 430212, Hubei, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
5.Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China
6.Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Hubei, Peoples R China
7.Wuhan Coll, Sch Informat & Commun, Wuhan 430212, Hubei, Peoples R China
8.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
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GB/T 7714
Zhu, Jiayan,Zhang, Wei,Li, Qizhai,et al. Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable[J]. SCIENTIFIC REPORTS,2017,7(8006):10.
APA Zhu, Jiayan.,Zhang, Wei.,Li, Qizhai.,Li, Zhengbang.,Zhu, Jiayan.,...&Li, Zhengbang.(2017).Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable.SCIENTIFIC REPORTS,7(8006),10.
MLA Zhu, Jiayan,et al."Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable".SCIENTIFIC REPORTS 7.8006(2017):10.
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