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Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable
Zhu, Jiayan1,2,3; Zhang, Wei4; Li, Qizhai4; Li, Zhengbang1,2; Zhu, Jiayan5,6,7; Zhang, Wei8; Li, Qizhai8; Li, Zhengbang5,6
2017-08-14
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Issue:8006Pages:10
Abstract

Multiple outcomes are often collected simultaneously in biomedical fields in order to identify whether a continuous response and an ordinal response are associated with some covariates simultaneously. Here we propose a joint statistical model by the use of a latent variable underlying the ordinal response. Asymptotic results are obtained and a jointly test is proposed for testing the continuous response and the ordinal response are associated with some covariates simultaneously. Extensive simulations and real data analysis results indicate more efficient performances of the proposed method than that of the combined p-values method.

DOI10.1038/s41598-017-08371-6
Language英语
Funding ProjectNational Nature Science Foundation of China[11401240] ; National Nature Science Foundation of China[11471135] ; Chinese Academy of Sciences[XDB13040600] ; Special National Key Research and Development Plan[2016YFD0400206]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000407559100006
PublisherNATURE PUBLISHING GROUP
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Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/26298
Collection系统科学研究所
Affiliation1.Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China
2.Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Hubei, Peoples R China
3.Wuhan Coll, Sch Informat & Commun, Wuhan 430212, Hubei, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
5.Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Hubei, Peoples R China
6.Cent China Normal Univ, Hubei Key Lab Math Sci, Wuhan 430079, Hubei, Peoples R China
7.Wuhan Coll, Sch Informat & Commun, Wuhan 430212, Hubei, Peoples R China
8.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Jiayan,Zhang, Wei,Li, Qizhai,et al. Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable[J]. SCIENTIFIC REPORTS,2017,7(8006):10.
APA Zhu, Jiayan.,Zhang, Wei.,Li, Qizhai.,Li, Zhengbang.,Zhu, Jiayan.,...&Li, Zhengbang.(2017).Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable.SCIENTIFIC REPORTS,7(8006),10.
MLA Zhu, Jiayan,et al."Testing Association between Mixed Type Outcomes and Covariates Jointly by the Use of a Latent Variable".SCIENTIFIC REPORTS 7.8006(2017):10.
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