Adverse drug reaction early warning using user search data

doi:10.1108/OIR-10-2015-0341

CSpace > 系统科学研究所

	Adverse drug reaction early warning using user search data
	Shang, Wei1 ; Chen, Hsinchun 2; Livoti, Christine 3
	2017
发表期刊	ONLINE INFORMATION REVIEW
ISSN	1468-4527
卷号	41 期号:4 页码:524-536
摘要	Purpose - The purpose of this paper is to propose a framework to detect adverse drug reactions (ADRs) using internet user search data, so that ADR events can be identified early. Empirical investigation of Avandia, a type II diabetes treatment, is conducted to illustrate how to implement the proposed framework. Design/methodology/approach - Typical ADR identification measures and time series processing techniques are used in the proposed framework. Google Trends Data are employed to represent user searches. The baseline model is a disproportionality analysis using official drug reaction reporting data from the US Food and Drug Administration's Adverse Event Reporting System. Findings - Results show that Google Trends series of Avandia side effects search reveal a significant early warning signal for the side effect emergence of Avandia. The proposed approach of using user search data to detect ADRs is proved to have a longer leading time than traditional drug reaction discovery methods. Three more drugs with known adverse reactions are investigated using the selected approach, and two are successfully identified. Research limitations/implications - Validation of Google Trends data's representativeness of user search is yet to be explored. In future research, user search in other search engines and in healthcare web forums can be incorporated to obtain a more comprehensive ADR early warning mechanism. Practical implications - Using internet data in drug safety management with a proper early warning mechanism may serve as an earlier signal than traditional drug adverse reaction. This has great potential in public health emergency management. Originality/value - The research work proposes a novel framework of using user search data in ADR identification. User search is a voluntary drug adverse reaction exploration behavior. Furthermore, user search data series are more concise and accurate than text mining in forums. The proposed methods as well as the empirical results will shed some light on incorporating user search data as a new source in pharmacovigilance.
关键词	Pharmacovigilance Google Trends Adverse drug reaction Diabetes treatment User search
DOI	10.1108/OIR-10-2015-0341
语种	英语
WOS研究方向	Computer Science ; Information Science & Library Science
WOS类目	Computer Science, Information Systems ; Information Science & Library Science
WOS记录号	WOS:000407682900006
出版者	EMERALD GROUP PUBLISHING LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/26281
专题	系统科学研究所
通讯作者	Shang, Wei
作者单位	1.Acad Math & Syst Sci, Beijing, Peoples R China 2.Univ Arizona, Tucson, AZ USA 3.Deerfield Inst, New York, NY USA
推荐引用方式 GB/T 7714	Shang, Wei,Chen, Hsinchun,Livoti, Christine. Adverse drug reaction early warning using user search data[J]. ONLINE INFORMATION REVIEW,2017,41(4):524-536.
APA	Shang, Wei,Chen, Hsinchun,&Livoti, Christine.(2017).Adverse drug reaction early warning using user search data.ONLINE INFORMATION REVIEW,41(4),524-536.
MLA	Shang, Wei,et al."Adverse drug reaction early warning using user search data".ONLINE INFORMATION REVIEW 41.4(2017):524-536.