KMS Of Academy of mathematics and systems sciences, CAS
| Additive mixed effect model for recurrent gap time data | |
Ding, Jieli1; Sun, Liuquan2
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| 2017-04-01 | |
| Source Publication | LIFETIME DATA ANALYSIS
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| ISSN | 1380-7870 |
| Volume | 23Issue:2Pages:223-253 |
| Abstract | Gap times between recurrent events are often of primary interest in medical and observational studies. The additive hazards model, focusing on risk differences rather than risk ratios, has been widely used in practice. However, the marginal additive hazards model does not take the dependence among gap times into account. In this paper, we propose an additive mixed effect model to analyze gap time data, and the proposed model includes a subject-specific random effect to account for the dependence among the gap times. Estimating equation approaches are developed for parameter estimation, and the asymptotic properties of the resulting estimators are established. In addition, some graphical and numerical procedures are presented for model checking. The finite sample behavior of the proposed methods is evaluated through simulation studies, and an application to a data set from a clinic study on chronic granulomatous disease is provided. |
| Keyword | Additive mixed effect model Estimating equation Gap times Random effects Recurrent event data |
| DOI | 10.1007/s10985-015-9341-0 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[11231010] ; National Natural Science Foundation of China[11101314] ; National Natural Science Foundation of China[11171330] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; BCMIIS |
| WOS Research Area | Mathematics |
| WOS Subject | Mathematics, Interdisciplinary Applications ; Statistics & Probability |
| WOS ID | WOS:000396792600004 |
| Publisher | SPRINGER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/25214 |
| Collection | 应用数学研究所 |
| Corresponding Author | Sun, Liuquan |
| Affiliation | 1.Wuhan Univ, Sch Math & Stat, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Ding, Jieli,Sun, Liuquan. Additive mixed effect model for recurrent gap time data[J]. LIFETIME DATA ANALYSIS,2017,23(2):223-253. |
| APA | Ding, Jieli,&Sun, Liuquan.(2017).Additive mixed effect model for recurrent gap time data.LIFETIME DATA ANALYSIS,23(2),223-253. |
| MLA | Ding, Jieli,et al."Additive mixed effect model for recurrent gap time data".LIFETIME DATA ANALYSIS 23.2(2017):223-253. |
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