Additive mixed effect model for recurrent gap time data

doi:10.1007/s10985-015-9341-0

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	Additive mixed effect model for recurrent gap time data
	Ding, Jieli 1; Sun, Liuquan2
	2017-04-01
发表期刊	LIFETIME DATA ANALYSIS
ISSN	1380-7870
卷号	23 期号:2 页码:223-253
摘要	Gap times between recurrent events are often of primary interest in medical and observational studies. The additive hazards model, focusing on risk differences rather than risk ratios, has been widely used in practice. However, the marginal additive hazards model does not take the dependence among gap times into account. In this paper, we propose an additive mixed effect model to analyze gap time data, and the proposed model includes a subject-specific random effect to account for the dependence among the gap times. Estimating equation approaches are developed for parameter estimation, and the asymptotic properties of the resulting estimators are established. In addition, some graphical and numerical procedures are presented for model checking. The finite sample behavior of the proposed methods is evaluated through simulation studies, and an application to a data set from a clinic study on chronic granulomatous disease is provided.
关键词	Additive mixed effect model Estimating equation Gap times Random effects Recurrent event data
DOI	10.1007/s10985-015-9341-0
语种	英语
资助项目	National Natural Science Foundation of China[11231010] ; National Natural Science Foundation of China[11101314] ; National Natural Science Foundation of China[11171330] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; BCMIIS
WOS研究方向	Mathematics
WOS类目	Mathematics, Interdisciplinary Applications ; Statistics & Probability
WOS记录号	WOS:000396792600004
出版者	SPRINGER
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/25214
专题	应用数学研究所
通讯作者	Sun, Liuquan
作者单位	1.Wuhan Univ, Sch Math & Stat, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ding, Jieli,Sun, Liuquan. Additive mixed effect model for recurrent gap time data[J]. LIFETIME DATA ANALYSIS,2017,23(2):223-253.
APA	Ding, Jieli,&Sun, Liuquan.(2017).Additive mixed effect model for recurrent gap time data.LIFETIME DATA ANALYSIS,23(2),223-253.
MLA	Ding, Jieli,et al."Additive mixed effect model for recurrent gap time data".LIFETIME DATA ANALYSIS 23.2(2017):223-253.