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Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition
Fan, Wei1,2; Lam, Sin Man1; Xin, Jingxue2,3; Yang, Xiao1,2; Liu, Zhonghua1; Liu, Yuan1,2; Wang, Yong3; Shui, Guanghou1; Huang, Xun1,2
2017-03-01
发表期刊PLOS GENETICS
ISSN1553-7404
卷号13期号:3页码:21
摘要The general transcription factor TBP (TATA-box binding protein) and its associated factors (TAFs) together form the TFIID complex, which directs transcription initiation. Through RNAi and mutant analysis, we identified a specific TBP family protein, TRF2, and a set of TAFs that regulate lipid droplet (LD) size in the Drosophila larval fat body. Among the three Drosophila TBP genes, trf2, tbp and trf1, only loss of function of trf2 results in increased LD size. Moreover, TRF2 and TAF9 regulate fatty acid composition of several classes of phospholipids. Through RNA profiling, we found that TRF2 and TAF9 affects the transcription of a common set of genes, including peroxisomal fatty acid beta-oxidation-related genes that affect phospholipid fatty acid composition. We also found that knockdown of several TRF2 and TAF9 target genes results in large LDs, a phenotype which is similar to that of trf2 mutants. Together, these findings provide new insights into the specific role of the general transcription machinery in lipid homeostasis.
DOI10.1371/journal.pgen.1006664
语种英语
资助项目Strategic Priority Research Program oft he Chinese Academy of Sciences[XDB13030300/0400] ; National Basic Research Program of China[2013CB530606] ; National Basic Research Program of China[2016YFA0500100] ; National Natural Science Foundation of China[11422108] ; National Natural Science Foundation of China[31325018] ; National Natural Science Foundation of China[31571377] ; National Natural Science Foundation of China[31630019]
WOS研究方向Genetics & Heredity
WOS类目Genetics & Heredity
WOS记录号WOS:000398043000040
出版者PUBLIC LIBRARY SCIENCE
引用统计
文献类型期刊论文
条目标识符http://ir.amss.ac.cn/handle/2S8OKBNM/25148
专题应用数学研究所
通讯作者Huang, Xun
作者单位1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing, Peoples R China
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Fan, Wei,Lam, Sin Man,Xin, Jingxue,et al. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition[J]. PLOS GENETICS,2017,13(3):21.
APA Fan, Wei.,Lam, Sin Man.,Xin, Jingxue.,Yang, Xiao.,Liu, Zhonghua.,...&Huang, Xun.(2017).Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition.PLOS GENETICS,13(3),21.
MLA Fan, Wei,et al."Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition".PLOS GENETICS 13.3(2017):21.
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