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Modeling the subdistribution of a competing risk
Sun, Liuquan; Liu, Jingxia; Sun, Jianguo; Zhang, Mei-Jie
2006-10-01
Source PublicationSTATISTICA SINICA
ISSN1017-0405
Volume16Issue:4Pages:1367-1385
AbstractCompeting risk failure time data occur frequently in medical studies, and a number of methods have been proposed for the analysis of these data. To assess covariate effects, a standard approach is to model the cause-specific hazard functions of different failure types. Recently, Fine and Gray (1999) proposed directly modeling the subdistribution of a competing risk with a Cox type model. In this paper, we consider a more flexible and general hazard model for the subdistribution. It is a combination of the additive model and the Cox model and allows one to perform a more detailed study of covariate effects. Inference procedures are developed for estimation of both parametric and nonparametric components of the model, and the asymptotic properties of the proposed estimators are established. Robust variance estimates along with some goodness-of-fit test procedures are also presented, and the prediction of the cumulative incidence function is discussed. The proposed methodology is applied to a set of competing risk data from a bone marrow transplant study.
Keywordadditive hazards model competing risk Cox model estimating functions prediction of cumulative incidence function
Language英语
WOS Research AreaMathematics
WOS SubjectStatistics & Probability
WOS IDWOS:000242276900016
PublisherSTATISTICA SINICA
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Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/2483
Collection应用数学研究所
Corresponding AuthorSun, Liuquan
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100080, Peoples R China
2.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
3.Univ Missouri, Dept Stat, Columbia, MO 65211 USA
Recommended Citation
GB/T 7714
Sun, Liuquan,Liu, Jingxia,Sun, Jianguo,et al. Modeling the subdistribution of a competing risk[J]. STATISTICA SINICA,2006,16(4):1367-1385.
APA Sun, Liuquan,Liu, Jingxia,Sun, Jianguo,&Zhang, Mei-Jie.(2006).Modeling the subdistribution of a competing risk.STATISTICA SINICA,16(4),1367-1385.
MLA Sun, Liuquan,et al."Modeling the subdistribution of a competing risk".STATISTICA SINICA 16.4(2006):1367-1385.
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