Modeling the subdistribution of a competing risk

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	Modeling the subdistribution of a competing risk
	Sun, Liuquan; Liu, Jingxia ; Sun, Jianguo ; Zhang, Mei-Jie
	2006-10-01
发表期刊	STATISTICA SINICA
ISSN	1017-0405
卷号	16 期号:4 页码:1367-1385
摘要	Competing risk failure time data occur frequently in medical studies, and a number of methods have been proposed for the analysis of these data. To assess covariate effects, a standard approach is to model the cause-specific hazard functions of different failure types. Recently, Fine and Gray (1999) proposed directly modeling the subdistribution of a competing risk with a Cox type model. In this paper, we consider a more flexible and general hazard model for the subdistribution. It is a combination of the additive model and the Cox model and allows one to perform a more detailed study of covariate effects. Inference procedures are developed for estimation of both parametric and nonparametric components of the model, and the asymptotic properties of the proposed estimators are established. Robust variance estimates along with some goodness-of-fit test procedures are also presented, and the prediction of the cumulative incidence function is discussed. The proposed methodology is applied to a set of competing risk data from a bone marrow transplant study.
关键词	additive hazards model competing risk Cox model estimating functions prediction of cumulative incidence function
语种	英语
WOS研究方向	Mathematics
WOS类目	Statistics & Probability
WOS记录号	WOS:000242276900016
出版者	STATISTICA SINICA
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/2483
专题	应用数学研究所
通讯作者	Sun, Liuquan
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100080, Peoples R China 2.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA 3.Univ Missouri, Dept Stat, Columbia, MO 65211 USA
推荐引用方式 GB/T 7714	Sun, Liuquan,Liu, Jingxia,Sun, Jianguo,et al. Modeling the subdistribution of a competing risk[J]. STATISTICA SINICA,2006,16(4):1367-1385.
APA	Sun, Liuquan,Liu, Jingxia,Sun, Jianguo,&Zhang, Mei-Jie.(2006).Modeling the subdistribution of a competing risk.STATISTICA SINICA,16(4),1367-1385.
MLA	Sun, Liuquan,et al."Modeling the subdistribution of a competing risk".STATISTICA SINICA 16.4(2006):1367-1385.