An Application of Invertibility of Boolean Control Networks to the Control of the Mammalian Cell Cycle

doi:10.1109/TCBB.2016.2515600

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	An Application of Invertibility of Boolean Control Networks to the Control of the Mammalian Cell Cycle
	Zhang, Kuize 1,2; Zhang, Lijun 1,3; Mou, Shaoshuai 4
	2017
发表期刊	IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
ISSN	1545-5963
卷号	14 期号:1 页码:225-229
摘要	In Faure et al. (2006), the dynamics of the core network regulating the mammalian cell cycle is formulated as a Boolean control network (BCN) model consisting of nine proteins as state nodes and a tenth protein (protein CycD) as the control input node. In this model, one of the state nodes, protein Cdc20, plays a central role in the separation of sister chromatids. Hence, if any Cdc20 sequence can be obtained, fully controlling the mammalian cell cycle is feasible. Motivated by this fact, we study whether any Cdc20 sequence can be obtained theoretically. We formulate the foregoing problem as the invertibility of BCNs, that is, whether one can obtain any Cdc20 sequence by designing input (i.e., protein CycD) sequences. We give an algorithm to verify the invertibility of any BCN, and find that the BCN model for the core network regulating the mammalian cell cycle is not invertible, that is, one cannot obtain any Cdc20 sequence. We further present another algorithm to test whether a finite Cdc20 sequence can be generated by the BCN model, which leads to a series of periodic infinite Cdc20 sequences with alternately active and inactive Cdc20 segments. States of these sequences are alternated between the two attractors in the proposed model, which reproduces correctly how a cell exits the cell cycle to enter the quiescent state, or the opposite.
关键词	Boolean control network invertibility mammalian cell cycle
DOI	10.1109/TCBB.2016.2515600
语种	英语
资助项目	National Natural Science Foundation of China[61573288] ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Basic Research Foundation of Northwestern Polytechnical University[JC201230]
WOS研究方向	Biochemistry & Molecular Biology ; Computer Science ; Mathematics
WOS类目	Biochemical Research Methods ; Computer Science, Interdisciplinary Applications ; Mathematics, Interdisciplinary Applications ; Statistics & Probability
WOS记录号	WOS:000395676900021
出版者	IEEE COMPUTER SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/24718
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Kuize
作者单位	1.Harbin Engn Univ, Coll Automat, Harbin 150001, Peoples R China 2.Chinese Acad Sci, Inst Syst Sci, Beijing 100190, Peoples R China 3.Northwest Polytech Univ, Sch Marine Technol, Xian 710072, Peoples R China 4.Purdue Univ, Sch Aeronaut & Astronaut, Indianapolis, IN 47907 USA
推荐引用方式 GB/T 7714	Zhang, Kuize,Zhang, Lijun,Mou, Shaoshuai. An Application of Invertibility of Boolean Control Networks to the Control of the Mammalian Cell Cycle[J]. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,2017,14(1):225-229.
APA	Zhang, Kuize,Zhang, Lijun,&Mou, Shaoshuai.(2017).An Application of Invertibility of Boolean Control Networks to the Control of the Mammalian Cell Cycle.IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,14(1),225-229.
MLA	Zhang, Kuize,et al."An Application of Invertibility of Boolean Control Networks to the Control of the Mammalian Cell Cycle".IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS 14.1(2017):225-229.