Identifying joint biomarker panel from multiple level dataset by an optimization model

doi:10.2217/bmm-2015-0022

CSpace > 应用数学研究所

	Identifying joint biomarker panel from multiple level dataset by an optimization model
	Zou, Meng 1; Zhang, Peng-Jun 2; Chen, Luonan 3; Tian, Ya-Ping 2; Wang, Yong1
	2016-06-01
发表期刊	BIOMARKERS IN MEDICINE
ISSN	1752-0363
卷号	10 期号:6 页码:567-575
摘要	Aim: Joint biomarker panel takes advantage of coherence across multiple level datasets and holds the promise to improve disease diagnosis accuracy. Methods: We collected 101 colorectal cancer and 95 benign samples, measured the molecular concentrations by serum assays and mass spectra, and developed LPGLO (Linear Programming based on Group Lasso Optimization) to identify the joint biomarker panel. Results: A joint biomarker panel, with ten serum biomarkers and six mass spectra peaks, achieves LOOCV accuracy 0.8724, which is better than the optimal panels identified from separate datasets (LOOCV = 0.7551 for mass spectra only or 0.8265 for serum assay only) and the simply merged dataset (LOOCV = 0.8622). Conclusion: LPGLO is useful to identify joint biomarker panel to help tumor diagnosis.
关键词	group lasso optimization joint biomarker panel multiple level dataset
DOI	10.2217/bmm-2015-0022
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13040700] ; National Natural Science Foundation of China (NSFC)[11422108] ; National Natural Science Foundation of China (NSFC)[11131009] ; NSFC[61134013] ; NSFC[91439103] ; NSFC[81071413] ; Knowledge Innovation Program of the Chinese Academy of Sciences (CAS)[KSCX2-EW-R-01] ; National High Technology Research and Development Program[2011AA02A111] ; China Postdoctoral Science Special Foundation[2014T70963] ; China Postdoctoral Science Foundation[2013M532110]
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000379503100003
出版者	FUTURE MEDICINE LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/23112
专题	应用数学研究所
通讯作者	Chen, Luonan; Tian, Ya-Ping; Wang, Yong
作者单位	1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Core Lab Translat Med, State Key Lab Kidney Dis, Beijing 100853, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Key Lab Syst Biol, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Zou, Meng,Zhang, Peng-Jun,Chen, Luonan,et al. Identifying joint biomarker panel from multiple level dataset by an optimization model[J]. BIOMARKERS IN MEDICINE,2016,10(6):567-575.
APA	Zou, Meng,Zhang, Peng-Jun,Chen, Luonan,Tian, Ya-Ping,&Wang, Yong.(2016).Identifying joint biomarker panel from multiple level dataset by an optimization model.BIOMARKERS IN MEDICINE,10(6),567-575.
MLA	Zou, Meng,et al."Identifying joint biomarker panel from multiple level dataset by an optimization model".BIOMARKERS IN MEDICINE 10.6(2016):567-575.