iSulf-Cys: Prediction of S-sulfenylation Sites in Proteins with Physicochemical Properties of Amino Acids

doi:10.1371/journal.pone.0154237

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	iSulf-Cys: Prediction of S-sulfenylation Sites in Proteins with Physicochemical Properties of Amino Acids
	Xu, Yan 1; Ding, Jun 1; Wu, Ling-Yun2
	2016-04-22
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	11 期号:4 页码:9
摘要	Cysteine S-sulfenylation is an important post-translational modification (PTM) in proteins, and provides redox regulation of protein functions. Bioinformatics and structural analyses indicated that S-sulfenylation could impact many biological and functional categories and had distinct structural features. However, major limitations for identifying cysteine S-sulfenylation were expensive and low-throughout. In view of this situation, the establishment of a useful computational method and the development of an efficient predictor are highly desired. In this study, a predictor iSulf-Cys which incorporated 14 kinds of physicochemical properties of amino acids was proposed. With the 10-fold cross-validation, the value of area under the curve (AUC) was 0.7155 +/- 0.0085, MCC 0.3122 +/- 0.0144 on the training dataset for 20 times. iSulf-Cys also showed satisfying performance in the independent testing dataset with AUC 0.7343 and MCC 0.3315. Features which were constructed from physicochemical properties and position were carefully analyzed. Meanwhile, a user-friendly webserver for iSulf-Cys is accessible at http://app.aporc.org/iSulf-Cys/.
DOI	10.1371/journal.pone.0154237
语种	英语
资助项目	Natural Science Foundation of China[11301024] ; Natural Science Foundation of China[31171263] ; Natural Science Foundation of China[81272578] ; Natural Science Foundation of China[J1103514] ; Fundamental Research Funds for the Central Universities[FRF-BR-15-075A]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000374565100059
出版者	PUBLIC LIBRARY SCIENCE
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/22641
专题	应用数学研究所
通讯作者	Xu, Yan
作者单位	1.Univ Sci & Technol Beijing, Dept Informat & Comp Sci, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yan,Ding, Jun,Wu, Ling-Yun. iSulf-Cys: Prediction of S-sulfenylation Sites in Proteins with Physicochemical Properties of Amino Acids[J]. PLOS ONE,2016,11(4):9.
APA	Xu, Yan,Ding, Jun,&Wu, Ling-Yun.(2016).iSulf-Cys: Prediction of S-sulfenylation Sites in Proteins with Physicochemical Properties of Amino Acids.PLOS ONE,11(4),9.
MLA	Xu, Yan,et al."iSulf-Cys: Prediction of S-sulfenylation Sites in Proteins with Physicochemical Properties of Amino Acids".PLOS ONE 11.4(2016):9.